C57BL/6JCya-Itga10em1/Cya
Common Name:
Itga10-KO
Product ID:
S-KO-04895
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Itga10-KO
Strain ID
KOCMP-213119-Itga10-B6J-VA
Gene Name
Product ID
S-KO-04895
Gene Alias
A630048L14
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Itga10em1/Cya mice (Catalog S-KO-04895) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000119365
NCBI RefSeq
NM_001302471
Target Region
Exon 16~27
Size of Effective Region
~5.3 kb
Detailed Document
Overview of Gene Research
Itga10, or integrin subunit alpha10, is an integrin that plays crucial roles in various biological processes. It is involved in the activation of the PI3K/AKT pathway [1,2,5]. This integrin is important for processes such as cell adhesion, migration, and differentiation, and is also associated with the extracellular matrix [4]. Genetic models can be valuable in studying its functions and implications in disease.
In osteosarcoma, knockdown of ZIP10, which promotes ITGA10 transcription and ITGA10-mediated PI3K/AKT pathway activation, suppressed cell proliferation and chemoresistance, indicating ITGA10's role in driving these processes in the disease [1]. In osteoblasts, miR-4739 inhibitor promoted cell proliferation, differentiation, and inhibited apoptosis by increasing ITGA10 expression and activating the PI3K/AKT pathway, suggesting ITGA10's importance in osteoblast function [2]. In alveolar bone marrow mesenchymal stem cells from type 2 diabetic patients, ITGA10 knockdown reduced adhesion, migration, and osteogenic differentiation by disturbing the FAK/PI3K/AKT/GSK3β/β-catenin pathway [5].
In conclusion, Itga10 is essential for functions like cell adhesion, migration, and differentiation, with its dysregulation contributing to diseases such as osteosarcoma, osteoporosis, and affecting osseointegration in type 2 diabetes. Studies using gene-knockdown models have been instrumental in revealing its role in these disease-related biological processes, providing potential therapeutic targets for treatment [1,2,5].
References:
1. Li, Hongyu, Shen, Xin, Ma, Mengjun, Wu, Yanfeng, Shen, Huiyong. 2021. ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway. In Journal of experimental & clinical cancer research : CR, 40, 340. doi:10.1186/s13046-021-02146-8. https://pubmed.ncbi.nlm.nih.gov/34706747/
2. Song, Yibo, Meng, Zhaolei, Zhang, Shanshan, Hu, Wei, Li, Hong. 2022. miR-4739/ITGA10/PI3K signaling regulates differentiation and apoptosis of osteoblast. In Regenerative therapy, 21, 342-350. doi:10.1016/j.reth.2022.08.002. https://pubmed.ncbi.nlm.nih.gov/36161100/
3. Tong, Wenwen, Li, Jia, Feng, Xinzhe, He, Chongru, Xu, Weidong. 2021. Kaiso regulates osteoblast differentiation and mineralization via the Itga10/PI3K/AKT signaling pathway. In International journal of molecular medicine, 47, . doi:10.3892/ijmm.2021.4874. https://pubmed.ncbi.nlm.nih.gov/33576467/
4. Soler-Sáez, Irene, Karz, Alcida, Hidalgo, Marta R, Hernando, Eva, García-García, Francisco. 2024. Unveiling Common Transcriptomic Features between Melanoma Brain Metastases and Neurodegenerative Diseases. In The Journal of investigative dermatology, 145, 1135-1146. doi:10.1016/j.jid.2024.09.005. https://pubmed.ncbi.nlm.nih.gov/39326662/
5. Liang, Chao, Liu, Xiu, Liu, Changying, Geng, Wei, Li, Jun. . Integrin α10 regulates adhesion, migration, and osteogenic differentiation of alveolar bone marrow mesenchymal stem cells in type 2 diabetic patients who underwent dental implant surgery. In Bioengineered, 13, 13252-13268. doi:10.1080/21655979.2022.2079254. https://pubmed.ncbi.nlm.nih.gov/35635091/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen