C57BL/6NCya-Tesem1/Cya
Common Name
Tes-KO
Product ID
S-KO-05308
Backgroud
C57BL/6NCya
Strain ID
KOCMP-21753-Tes-B6N-VA
When using this mouse strain in a publication, please cite “Tes-KO Mouse (Catalog S-KO-05308) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Tes-KO
Strain ID
KOCMP-21753-Tes-B6N-VA
Gene Name
Product ID
S-KO-05308
Gene Alias
TESS, Tes1, Tes2, testin2, D6Ertd352e
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 6
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000115467
NCBI RefSeq
NM_207176
Target Region
Exon 3~6
Size of Effective Region
~4.3 kb
Overview of Gene Research
Tes, also known as testin LIM domain protein, is a candidate tumor suppressor gene. It contains three LIM domains which interact with cell adhesion and cytoskeleton regulatory proteins. TES may play a role in regulating cell adhesion, motility, and proliferation through its interactions with cytoskeleton-related proteins [1].
In gastric cancer, TES functions as a Mena-dependent tumor suppressor. In vitro cell proliferation assay, colony formation assay, cell cycle analysis, Transwell assays, and in vivo tumorigenicity and metastasis assays showed that TES suppressed gastric cancer cell proliferation, colony formation, induced cell cycle arrest, inhibited migration, invasion, and metastasis. TES interacted with Mena and inhibited the interaction of Mena with Lpd, suppressing cell migration and invasion in a Mena-dependent manner. In gastric cancer patients with high Mena expression, TES expression was associated with tumor infiltration, lymph node metastasis, TNM stage, and prognosis [1].
In conclusion, Tes is a tumor suppressor gene with potential significance in gastric cancer. Its function as a Mena-dependent tumor suppressor reveals its importance in regulating cancer-related biological processes such as carcinogenesis and metastasis. The study of Tes in gastric cancer using in vivo models provides insights into the mechanisms of cancer development and potential therapeutic targets [1].
References:
1. Wang, Dan-Dan, Chen, Yi-Bing, Zhao, Jing-Jing, Wang, Lei-Lei, Xia, Jian-Chuan. 2019. TES functions as a Mena-dependent tumor suppressor in gastric cancer carcinogenesis and metastasis. In Cancer communications (London, England), 39, 3. doi:10.1186/s40880-019-0347-y. https://pubmed.ncbi.nlm.nih.gov/30728082/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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