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C57BL/6JCya-Gimap6em1/Cya
Common Name:
Gimap6-KO
Product ID:
S-KO-06493
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Gimap6-KO
Strain ID
KOCMP-231931-Gimap6-B6J-VB
Gene Name
Gimap6
Product ID
S-KO-06493
Gene Alias
4833419H03Rik; Ian6; mFLJ00102
Background
C57BL/6JCya
NCBI ID
231931
Modification
Conventional knockout
Chromosome
6
Phenotype
MGI:1918876
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Gimap6em1/Cya mice (Catalog S-KO-06493) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000053661
NCBI RefSeq
NM_153175
Target Region
Exon 2
Size of Effective Region
~1.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
GIMAP6, the GTPase of the immune-associated protein 6, is a gene crucial for autophagy, immune competence, and inflammation [1,2]. It is part of the GIMAP GTPase family, which are prominently expressed in the adaptive immune system. GIMAP6 is involved in pathways such as redox regulation, and its expression can be induced by IFN-γ, playing a critical role in antibacterial immunity [1].

In Gimap6-/-mice, there are defects in autophagy, redox regulation, and polyunsaturated fatty acid-containing lipids. Mice with Gimap6 gene deletion in T and B cell lineages have a 50-70% reduction in peripheral CD4+ and CD8+ T cells, along with autophagic disruption as indicated by increased levels of MAP1LC3B (especially lipidated LC3-II form) and S405-phosphorylation of SQSTM1, and an increased mitochondrial/cytoplasmic volume ratio and autophagosome numbers [2]. Gimap6-/-mice also died prematurely from microangiopathic glomerulosclerosis, likely due to GIMAP6 deficiency in kidney endothelial cells [1]. In human patients with GIMAP6 mutations, they show infections, lymphoproliferation, autoimmunity, and multiorgan vasculitis, along with defects in autophagy and redox regulation [1].

In conclusion, GIMAP6 is essential for normal autophagic processes and the maintenance of a normal peripheral adaptive immune system. Studies on Gimap6-/-mouse models have revealed its role in various disease-related conditions such as microangiopathic glomerulosclerosis in mice and inborn errors of immunity in humans, highlighting its significance in understanding immune-related diseases [1,2].

References:

1. Yao, Yikun, Du Jiang, Ping, Chao, Brittany N, Simon, Anna Katharina, Lenardo, Michael J. 2022. GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans. In The Journal of experimental medicine, 219, . doi:10.1084/jem.20201405. https://pubmed.ncbi.nlm.nih.gov/35551368/

2. Pascall, John C, Webb, Louise M C, Eskelinen, Eeva-Liisa, Attaf-Bouabdallah, Noudjoud, Butcher, Geoffrey W. 2018. GIMAP6 is required for T cell maintenance and efficient autophagy in mice. In PloS one, 13, e0196504. doi:10.1371/journal.pone.0196504. https://pubmed.ncbi.nlm.nih.gov/29718959/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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