C57BL/6NCya-Ankmy1em1/Cya
Common Name:
Ankmy1-KO
Product ID:
S-KO-07271
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Ankmy1-KO
Strain ID
KOCMP-241158-Ankmy1-B6N-VA
Gene Name
Product ID
S-KO-07271
Gene Alias
4930483I10Rik; ZMYND13
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
1
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Ankmy1em1/Cya mice (Catalog S-KO-07271) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000112998
NCBI RefSeq
NM_172850
Target Region
Exon 3~4
Size of Effective Region
~3.6 kb
Detailed Document
Overview of Gene Research
Ankmy1, whose function has been explored in multiple research contexts, is associated with cytoskeleton organization regulation [2]. It is likely involved in processes that maintain the structural integrity and function of cells by influencing the cytoskeleton. However, the exact molecular mechanisms and associated pathways remain to be fully elucidated, and genetic models could potentially shed more light on its function.
In osteosarcoma (OS), analysis of relevant datasets showed that the dysregulation of Ankmy1, among other genes, was associated with the metastasis-free survival time in patients [1]. This indicates that Ankmy1 may play a role in the progression of osteosarcoma.
In conclusion, Ankmy1 appears to be important in both normal cellular cytoskeleton-related processes and in the context of osteosarcoma, where its dysregulation is linked to patient metastasis-free survival. Further in-vivo studies, such as gene knockout (KO) or conditional knockout (CKO) mouse models, could potentially uncover more about its function in these disease-related biological processes [1,2].
References:
1. Wang, Fei, Qin, Guoqing, Liu, Junzhi, Wang, Xiunan, Ye, Baoguo. 2020. Integrated Genome-Wide Methylation and Expression Analyses Reveal Key Regulators in Osteosarcoma. In Computational and mathematical methods in medicine, 2020, 7067649. doi:10.1155/2020/7067649. https://pubmed.ncbi.nlm.nih.gov/32855654/
2. Svirid, A V, Ershov, P V, Yablokov, E O, Medvedev, A E, Ivanov, A S. . Direct Molecular Fishing of New Protein Partners for Human Thromboxane Synthase. In Acta naturae, 9, 92-100. doi:. https://pubmed.ncbi.nlm.nih.gov/29340222/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen