BC048671 is a gene enriched in male reproductive tissues. However, its exact function, associated pathways, and overall biological importance were not initially clear, highlighting the value of genetic models like KO mouse models for its study.

In a study, gene-deficient mouse models were established using the Nuclease technology system. BC048671-deficient mice were among the 13 generated. Surprisingly, these gene-deficient mice exhibited normal fertility in natural breeding experiments, indicating that BC048671 is not essential for male fertility [1].

In conclusion, based on the KO mouse model research, BC048671, despite being enriched in male reproductive tissues, is dispensable for male fertility. This finding helps in the efficient allocation of research resources in male reproductive biology by preventing redundant efforts in generating knockout mice for genes without an apparent male-fertility-related phenotype [1].

References:

1. Nguyen, Tuyen Thi Thanh, Tokuhiro, Keizo, Shimada, Keisuke, Kiyozumi, Daiji, Ikawa, Masahito. 2024. Gene-deficient mouse model established by Nuclease technology system reveals 15 reproductive organ-enriched genes dispensable for male fertility. In Frontiers in cell and developmental biology, 12, 1411162. doi:10.3389/fcell.2024.1411162. https://pubmed.ncbi.nlm.nih.gov/38835510/