C57BL/6JCya-BC048671em1/Cya
Common Name
BC048671-KO
Product ID
S-KO-07445
Backgroud
C57BL/6JCya
Strain ID
KOCMP-243535-BC048671-B6J-VA
When using this mouse strain in a publication, please cite “BC048671-KO Mouse (Catalog S-KO-07445) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
BC048671-KO
Strain ID
KOCMP-243535-BC048671-B6J-VA
Gene Name
Product ID
S-KO-07445
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 6
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000054799
NCBI RefSeq
NM_177738
Target Region
Exon 3~5
Size of Effective Region
~3.0 kb
Overview of Gene Research
BC048671 is a gene enriched in male reproductive tissues. However, its exact function, associated pathways, and overall biological importance were not initially clear, highlighting the value of genetic models like KO mouse models for its study.
In a study, gene-deficient mouse models were established using the CRISPR/Cas9 system. BC048671-deficient mice were among the 13 generated. Surprisingly, these gene-deficient mice exhibited normal fertility in natural breeding experiments, indicating that BC048671 is not essential for male fertility [1].
In conclusion, based on the KO mouse model research, BC048671, despite being enriched in male reproductive tissues, is dispensable for male fertility. This finding helps in the efficient allocation of research resources in male reproductive biology by preventing redundant efforts in generating knockout mice for genes without an apparent male-fertility-related phenotype [1].
References:
1. Nguyen, Tuyen Thi Thanh, Tokuhiro, Keizo, Shimada, Keisuke, Kiyozumi, Daiji, Ikawa, Masahito. 2024. Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. In Frontiers in cell and developmental biology, 12, 1411162. doi:10.3389/fcell.2024.1411162. https://pubmed.ncbi.nlm.nih.gov/38835510/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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