Tmem255a, Transmembrane Protein 255A, is a gene whose exact function is still being elucidated. From current research, it seems to be involved in immune-related and inflammation-associated pathways [1,2].

In a mouse model of fetal growth restriction (FGR) with nitric oxide deficiency, Tmem255a was among the differentially expressed genes in the placenta. It was upregulated in FGR-affected placentas, suggesting its potential role in the immune system and inflammatory signaling pathways during FGR development [2]. In uveal melanoma, high-expressed TMEM255A was associated with poor prognosis, indicating its possible involvement in tumor-related biological processes [1].

In conclusion, Tmem255a appears to play roles in immune-related functions, inflammation regulation, and potentially in tumor-associated processes. The mouse model of FGR provided insights into its role in FGR-related pathologies, highlighting its importance in understanding the pathophysiology of such conditions.

References:

1. Gao, Guohong, Yu, Zhilong, Zhao, Xiaoyan, Liang, Shan, Deng, Aijun. 2021. Immune classification and identification of prognostic genes for uveal melanoma based on six immune cell signatures. In Scientific reports, 11, 22244. doi:10.1038/s41598-021-01627-2. https://pubmed.ncbi.nlm.nih.gov/34782661/

2. Huang, Shiyun, He, Xin, Bian, Xiaotao, Li, Zhengpeng, Chen, Yi. 2025. Placental transcriptomic profiling in a mouse model of fetal growth restriction reveals disturbed inflammation and immunity regulation†. In Biology of reproduction, , . doi:10.1093/biolre/ioaf083. https://pubmed.ncbi.nlm.nih.gov/40207873/