C57BL/6JCya-Tmem255aem1/Cya
Common Name
Tmem255a-KO
Product ID
S-KO-07583
Backgroud
C57BL/6JCya
Strain ID
KOCMP-245386-Tmem255a-B6J-VA
When using this mouse strain in a publication, please cite “Tmem255a-KO Mouse (Catalog S-KO-07583) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Tmem255a-KO
Strain ID
KOCMP-245386-Tmem255a-B6J-VA
Gene Name
Product ID
S-KO-07583
Gene Alias
Fam70a, 4933417N17, 6430550H21Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr X
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000066498
NCBI RefSeq
NM_172930
Target Region
Exon 2
Size of Effective Region
~0.8 kb
Overview of Gene Research
Tmem255a, Transmembrane Protein 255A, is a gene whose exact function is still being elucidated. From current research, it seems to be involved in immune-related and inflammation-associated pathways [1,2].
In a mouse model of fetal growth restriction (FGR) with nitric oxide deficiency, Tmem255a was among the differentially expressed genes in the placenta. It was upregulated in FGR-affected placentas, suggesting its potential role in the immune system and inflammatory signaling pathways during FGR development [2]. In uveal melanoma, high-expressed TMEM255A was associated with poor prognosis, indicating its possible involvement in tumor-related biological processes [1].
In conclusion, Tmem255a appears to play roles in immune-related functions, inflammation regulation, and potentially in tumor-associated processes. The mouse model of FGR provided insights into its role in FGR-related pathologies, highlighting its importance in understanding the pathophysiology of such conditions.
References:
1. Gao, Guohong, Yu, Zhilong, Zhao, Xiaoyan, Liang, Shan, Deng, Aijun. 2021. Immune classification and identification of prognostic genes for uveal melanoma based on six immune cell signatures. In Scientific reports, 11, 22244. doi:10.1038/s41598-021-01627-2. https://pubmed.ncbi.nlm.nih.gov/34782661/
2. Huang, Shiyun, He, Xin, Bian, Xiaotao, Li, Zhengpeng, Chen, Yi. 2025. Placental transcriptomic profiling in a mouse model of fetal growth restriction reveals disturbed inflammation and immunity regulation†. In Biology of reproduction, , . doi:10.1093/biolre/ioaf083. https://pubmed.ncbi.nlm.nih.gov/40207873/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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