C57BL/6JCya-Or4d5em1/Cya
Common Name
Or4d5-KO
Product ID
S-KO-08040
Backgroud
C57BL/6JCya
Strain ID
KOCMP-258601-Or4d5-B6J-VA
When using this mouse strain in a publication, please cite “Or4d5-KO Mouse (Catalog S-KO-08040) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Or4d5-KO
Strain ID
KOCMP-258601-Or4d5-B6J-VA
Gene Name
Product ID
S-KO-08040
Gene Alias
Olfr984, MOR239-6
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 9
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000056795
NCBI RefSeq
NM_146608
Target Region
Exon 1
Size of Effective Region
~0.9 kb
Overview of Gene Research
Or4d5 is a gene, though specific key aliases, its essential function, associated pathways and overall biological importance remain relatively unknown. However, genes of the Or (olfactory receptor) family are generally involved in the detection of odorants and play a role in the olfactory sensory system [1].
The study aimed to generate a genomic atlas of human adrenal and gonad development. It was found that the developing human ovary expresses distinct subsets of genes, including Or4d5, but enrichment for established biological pathways was limited [1].
In conclusion, while the exact biological function of Or4d5 is yet to be fully elucidated, its expression in the developing human ovary as revealed by the genomic atlas study indicates its potential significance in ovarian development. Future functional studies, such as gene knockout or conditional knockout in mouse models, could potentially shed more light on its role in specific biological processes or disease conditions related to the ovary. [1]
References:
1. Del Valle, Ignacio, Buonocore, Federica, Duncan, Andrew J, Gerrelli, Dianne, Achermann, John C. 2017. A genomic atlas of human adrenal and gonad development. In Wellcome open research, 2, 25. doi:10.12688/wellcomeopenres.11253.2. https://pubmed.ncbi.nlm.nih.gov/28459107/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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