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C57BL/6NCya-Tango6em1/Cya
Common Name:
Tango6-KO
Product ID:
S-KO-08860
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Tango6-KO
Strain ID
KOCMP-272538-Tango6-B6N-VA
Gene Name
Tango6
Product ID
S-KO-08860
Gene Alias
E330010G16; Tmco7
Background
C57BL/6NCya
NCBI ID
272538
Modification
Conventional knockout
Chromosome
8
Phenotype
MGI:2142786
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Tango6em1/Cya mice (Catalog S-KO-08860) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000048359
NCBI RefSeq
NM_173037
Target Region
Exon 2~3
Size of Effective Region
~4.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Tango6 is a gene associated with the coat protein complex I (COPI) vesicle trafficking system. It plays a crucial role in regulating cell proliferation. Tango6 functions by mediating the retrograde transfer of cargo between Golgi cisternae and from the Golgi to the endoplasmic reticulum (ER), and is involved in the cell cycle progression pathway. Its importance lies in the regulation of cell expansion, making it a potential target for promoting or arresting cell growth [1].

In mouse hematopoietic stem cells, conditional depletion or overexpression of Tango6 leads to compromised or expanded hematopoiesis respectively [1]. In zebrafish, homozygous tango6cq72 mutants show defective expansion of hematopoietic stem and progenitor cells (HSPCs) in the caudal hematopoietic tissue (CHT) and compromised hematopoiesis, while hematopoietic overexpression of Tango6 promotes hematopoietic expansion. tango6 deficiency causes a decline in RNA polymerase II subunit B and accumulation of DNA damage, suppressing cell expansion in a P53-dependent manner [2].

In conclusion, Tango6, through its association with COPI vesicles, plays a significant role in regulating cell cycle progression and hematopoiesis. The conditional knockout and overexpression studies in mouse and zebrafish models have revealed its importance in these biological processes, potentially providing insights for diseases related to abnormal cell proliferation and hematopoiesis [1,2].

References:

1. Feng, Zhi, Liu, Shengnan, Su, Ming, Luo, Lingfei, Li, Li. 2024. TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry. In Nature communications, 15, 2371. doi:10.1038/s41467-024-46720-y. https://pubmed.ncbi.nlm.nih.gov/38490996/

2. Liu, Shengnan, Feng, Zhi, Su, Ming, Zhao, Fangying, Li, Li. 2025. Tango6 regulates HSPC proliferation and definitive haematopoiesis via Ikzf1 and Cmyb in caudal haematopoietic tissue. In Development (Cambridge, England), 152, . doi:10.1242/dev.202903. https://pubmed.ncbi.nlm.nih.gov/39620979/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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