C57BL/6NCya-A530016L24Rikem1/Cya
Common Name
A530016L24Rik-KO
Product ID
S-KO-09215
Backgroud
C57BL/6NCya
Strain ID
KOCMP-319942-A530016L24Rik-B6N-VA
When using this mouse strain in a publication, please cite “A530016L24Rik-KO Mouse (Catalog S-KO-09215) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
A530016L24Rik-KO
Strain ID
KOCMP-319942-A530016L24Rik-B6N-VA
Gene Name
Product ID
S-KO-09215
Gene Alias
Nrac
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 12
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000057465
NCBI RefSeq
NM_177039
Target Region
Exon 2~5
Size of Effective Region
~3.1 kb
Overview of Gene Research
A530016L24Rik, also named Nrac with human ortholog C14orf180, is a gene with potential functions in metabolism. It may be involved in pathways related to adipose and cardiac metabolism, and its study using genetic models could provide insights into these biological processes [1].
RNA-Seq on fat in mice treated with a high-fat diet or fasting showed that Nrac is specifically and abundantly expressed in fat and the heart. Both fasting and obesity reduced its expression in white adipose tissue, and fasting decreased its expression in brown fat. It is localized to the plasma membrane and highly induced during adipocyte differentiation [1].
In conclusion, A530016L24Rik (Nrac) is a nutritionally-regulated gene enriched in adipose and cardiac tissues. Its expression changes in response to fasting and obesity, suggesting its role in metabolism-related processes. The mouse-based studies contribute to understanding its potential function in obesity-related metabolic disorders [1].
References:
1. Zhang, Ren, Yao, Fayi, Gao, Feng, Abou-Samra, Abdul B. 2012. Nrac, a novel nutritionally-regulated adipose and cardiac-enriched gene. In PloS one, 7, e46254. doi:10.1371/journal.pone.0046254. https://pubmed.ncbi.nlm.nih.gov/23029450/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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