C57BL/6JCya-Tcp11l1em1/Cya
Common Name:
Tcp11l1-KO
Product ID:
S-KO-09308
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Tcp11l1-KO
Strain ID
KOCMP-320554-Tcp11l1-B6J-VA
Gene Name
Product ID
S-KO-09308
Gene Alias
C130096D04Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tcp11l1em1/Cya mice (Catalog S-KO-09308) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000028597
NCBI RefSeq
NM_177190
Target Region
Exon 4
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Tcp11l1, as of now, has no widely-known common aliases. Specific essential functions, associated pathways, and its overall biological importance are not clearly elaborated in the provided references. However, genetic models could potentially be valuable for further in-depth functional studies.
One study identified that in a patient with cryptorchidism and non-obstructive azoospermia, a novel approximately 1 Mb microdeletion at 11p13 spanned nine genes including TCP11L1 [1]. Another study found that DNA methylation at cg17485717 (annotated to TCP11L1) mediated 30.5% of cadmium-associated activities of daily living (ADL) disability prevalence, suggesting a potential link between TCP11L1 DNA methylation and heavy-metal-related ADL disability [2].
In summary, while direct evidence from gene-knockout (KO) or conditional-knockout (CKO) mouse models is lacking in the provided references, the identified microdeletion in a patient with reproductive disorders and the DNA methylation-mediated association with ADL disability hint at possible involvement of Tcp11l1 in these disease-related processes. Further research using KO or CKO mouse models could potentially reveal more about its biological functions and contributions to these and other disease areas.
References:
1. Seabra, Catarina M, Quental, Sofia, Neto, Ana Paula, Amorim, António, Lopes, Alexandra M. 2014. A novel Alu-mediated microdeletion at 11p13 removes WT1 in a patient with cryptorchidism and azoospermia. In Reproductive biomedicine online, 29, 388-91. doi:10.1016/j.rbmo.2014.04.017. https://pubmed.ncbi.nlm.nih.gov/24912414/
2. Xiao, Lili, Cheng, Hong, Cai, Haiqing, Zou, Yunfeng, Yang, Xiaobo. 2022. Associations of Heavy Metals with Activities of Daily Living Disability: An Epigenome-Wide View of DNA Methylation and Mediation Analysis. In Environmental health perspectives, 130, 87009. doi:10.1289/EHP10602. https://pubmed.ncbi.nlm.nih.gov/36036794/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen