Thap6 is a novel transcription factor (TF). Although specific aliases are not provided in the given reference, as a TF, it is likely involved in regulating gene expression, which is crucial for various biological processes. However, the exact associated pathways and its overall biological importance are yet to be fully elaborated based on this single reference. Genetic models could potentially be valuable in further exploring its functions [1].

The study using promoter-level expression profiling by non-biased deepCAGE on classically and alternatively activated macrophages suggested that Thap6 might be involved in the activation processes of classically activated macrophages (M1). It was among the novel TFs identified, indicating a potential role in the transcriptional regulatory dynamics of M1 macrophage activation [1].

In conclusion, Thap6, as a newly identified transcription factor, shows promise in being involved in the transcriptional machinery of macrophage activation, specifically in M1 macrophages. While more research is needed, the discovery through this study contributes to understanding the role of Thap6 in macrophage-related immune responses, which could potentially impact our understanding of diseases associated with macrophage dysregulation [1].

References:

1. Roy, Sugata, Schmeier, Sebastian, Arner, Erik, Brombacher, Frank, Suzuki, Harukazu. 2015. Redefining the transcriptional regulatory dynamics of classically and alternatively activated macrophages by deepCAGE transcriptomics. In Nucleic acids research, 43, 6969-82. doi:10.1093/nar/gkv646. https://pubmed.ncbi.nlm.nih.gov/26117544/