C57BL/6JCya-Clec2mem1/Cya
Common Name:
Clec2m-KO
Product ID:
S-KO-09813
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Clec2m-KO
Strain ID
KOCMP-381816-Clec2m-B6J-VA
Gene Name
Product ID
S-KO-09813
Gene Alias
4922502D21Rik; Gm1074; SPATA78
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
6
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Clec2mem1/Cya mice (Catalog S-KO-09813) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000051283
NCBI RefSeq
NM_199034
Target Region
Exon 1~5
Size of Effective Region
~9.0 kb
Detailed Document
Overview of Gene Research
Clec2m is a novel gene within the context of the rat natural killer cell gene complex (NKC). The NKC encodes receptors from the C-type lectin superfamily expressed mainly by NK cells and other leukocytes [1]. Although the specific function, associated pathways, and overall biological importance of Clec2m are not detailed in the provided abstract, its study within the NKC framework could potentially offer insights into immune-related biological processes.
The cDNA cloning and transcription patterns of Clec2m were presented as part of closing the gap between the Nkrp1/Clr and the Klre1-Klri2 clusters in the rat NKC. This gene was among eight genes spanning from Cd69 to Dectin1 [1].
In conclusion, while the exact biological functions of Clec2m are yet to be fully elucidated, its inclusion in the study of the rat NKC through cDNA cloning and transcription pattern analysis may help uncover its role in immune-related processes, contributing to a better understanding of the NKC's organization, evolution, and function in the context of the rat immune system.
References:
1. Flornes, Line M, Nylenna, Øyvind, Saether, Per C, Dissen, Erik, Fossum, Sigbjørn. 2010. The complete inventory of receptors encoded by the rat natural killer cell gene complex. In Immunogenetics, 62, 521-30. doi:10.1007/s00251-010-0455-y. https://pubmed.ncbi.nlm.nih.gov/20544345/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen