C57BL/6NCya-Rhox1em1/Cya
Common Name
Rhox1-KO
Product ID
S-KO-09915
Backgroud
C57BL/6NCya
Strain ID
KOCMP-385343-Rhox1-B6N-VA
Status
When using this mouse strain in a publication, please cite “Rhox1-KO Mouse (Catalog S-KO-09915) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Rhox1-KO
Strain ID
KOCMP-385343-Rhox1-B6N-VA
Gene Name
Product ID
S-KO-09915
Gene Alias
--
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr X
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000115210
NCBI RefSeq
NM_001025084
Target Region
Exon 1~5
Size of Effective Region
~8.2 kb
Overview of Gene Research
Rhox1, a gene within the reproductive homeobox on the X chromosome (RHOX) gene family, has a crucial role in reproduction. The RHOX genes, which are conserved in mammals, are involved in regulating the progression of embryonic development and have key functions in gametogenesis [1,2].
In mouse models, Rhox genes are mainly expressed in reproductive tissues. Rhox1, in particular, has been found to play a role in the differentiation of primordial germ cells and in spermatogenesis [1]. These findings from in vivo studies in mice suggest that Rhox1 is essential for normal reproductive processes, highlighting the value of mouse models in functional studies of this gene.
In conclusion, Rhox1 is an important gene in the RHOX family, with essential functions in reproduction, especially in primordial germ cell differentiation and spermatogenesis. The use of KO/CKO mouse models has provided valuable insights into these functions, which may be relevant to understanding infertility and other reproductive-related diseases [1].
References:
1. Le Beulze, Morgane, Daubech, Cécile, Balde-Camara, Aissatu, Ghieh, Farah, Vialard, François. 2023. Mammal Reproductive Homeobox (Rhox) Genes: An Update of Their Involvement in Reproduction and Development. In Genes, 14, . doi:10.3390/genes14091685. https://pubmed.ncbi.nlm.nih.gov/37761825/
2. Lee, Sang-Eun, Lee, Su-Yeon, Lee, Kyung-Ah. 2013. Rhox in mammalian reproduction and development. In Clinical and experimental reproductive medicine, 40, 107-14. doi:10.5653/cerm.2013.40.3.107. https://pubmed.ncbi.nlm.nih.gov/24179867/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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