C57BL/6JCya-Gm5532em1/Cya
Common Name
Gm5532-KO
Product ID
S-KO-10077
Backgroud
C57BL/6JCya
Strain ID
KOCMP-433367-Gm5532-B6J-VA
When using this mouse strain in a publication, please cite “Gm5532-KO Mouse (Catalog S-KO-10077) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Gm5532-KO
Strain ID
KOCMP-433367-Gm5532-B6J-VA
Gene Name
Product ID
S-KO-10077
Gene Alias
EG433367
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 1
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000097531
NCBI RefSeq
NR_132128
Target Region
Exon 2
Size of Effective Region
~3.0 kb
Overview of Gene Research
Gm5532 is a long noncoding RNA (lncRNA) with significant importance in bone metabolism. It functions as a regulator in osteoclast-related processes, and is involved in the miR-125a-3p/TRAF6 axis, which is crucial for understanding its role in bone-related biological pathways [1].
lncRNA microarray analysis identified Gm5532 as highly expressed during osteoclast differentiation. Knockdown of lncRNA-Gm5532 impairs osteoclast formation and bone resorption. Mechanistically, it acts as a competing endogenous RNA (ceRNA), sponging miR-125a-3p, thus promoting TNF receptor-associated factor 6 (TRAF6) expression. miR-125a-3p mimics suppress osteoclast differentiation and TAK1/NF-κB/MAPK signaling, while its inhibitor reverses the negative effects of siGm5532 on osteoclast differentiation [1].
In conclusion, Gm5532 functions as an activator in osteoclast differentiation by targeting the miR-125a-3p/TRAF6 axis. The study of Gm5532 knockdown in the context of osteoclast differentiation reveals its potential as a novel biomarker and therapeutic target for osteoporosis [1].
References:
1. Zhang, Jian, Zhang, Lingyan, Yao, Gang, Qiao, Penghai, Wu, Shuguang. . lncRNA-Gm5532 regulates osteoclast differentiation through the miR-125a-3p/TRAF6 axis. In Acta biochimica et biophysica Sinica, 56, 54-61. doi:10.3724/abbs.2023245. https://pubmed.ncbi.nlm.nih.gov/38098360/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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