Ccdc185, a gene of which specific functions and associated pathways are still being elucidated, was recently identified in a study on Primary Ovarian Insufficiency (POI) [1]. Its biological importance may be related to the pathophysiology of POI, hinting at potential roles in ovarian function-related processes.

In a study of a large cohort of POI patients, strong evidence of pathogenicity for Ccdc185 was found, suggesting its involvement in the molecular pathophysiology of POI [1]. Although no KO/CKO mouse models are mentioned in the given abstract, this discovery implies Ccdc185 could play a causal role in the development of POI.

In conclusion, Ccdc185 has been newly associated with POI, suggesting it may be crucial in maintaining normal ovarian function. The identification of Ccdc185's pathogenicity in POI patients contributes to understanding the genetic landscape of this disease, potentially leading to new diagnostic and therapeutic strategies for POI [1].

References:

1. Heddar, Abdelkader, Ogur, Cagri, Da Costa, Sabrina, Catteau-Jonard, Sophie, Misrahi, Micheline. 2022. Genetic landscape of a large cohort of Primary Ovarian Insufficiency: New genes and pathways and implications for personalized medicine. In EBioMedicine, 84, 104246. doi:10.1016/j.ebiom.2022.104246. https://pubmed.ncbi.nlm.nih.gov/36099812/