Aa467197, also known as Nmes1 (Normal Mucosa of Esophagus-Specific gene 1), is a novel regulator of mucosal healing. It influences the macrophage response to the tissue remodeling cytokine IL-4, suggesting its involvement in pathways related to tissue remodeling and immune-mediated responses. Understanding its function is crucial for developing new therapies for intestinal-associated inflammation [1].

In murine models, Nmes1 ablation led to decreased intestinal regeneration during colitis recovery, while enhancing parasitic egg clearance and reducing fibrosis during advanced Schistosoma mansoni infection. These effects were associated with alterations in CX3CR1+ macrophages, known for wound-healing in the inflamed colon. This indicates that Nmes1 plays a role in different intestinal disease-related processes [1].

In summary, Aa467197 (Nmes1) is an important regulator of mucosal healing. Gene-knockout mouse models have revealed its role in colitis and Schistosoma mansoni-related intestinal conditions, providing a basis for further exploration as a potential target for treating colon-associated inflammation. [1]

References:

1. Hamley, Madeleine, Leyk, Stephanie, Casar, Christian, Henao-Mejia, Jorge, Bosurgi, Lidia. 2023. Nmes1 is a novel regulator of mucosal response influencing intestinal healing potential. In European journal of immunology, 54, e2350434. doi:10.1002/eji.202350434. https://pubmed.ncbi.nlm.nih.gov/37971166/