C57BL/6JCya-Igbp1bem1/Cya
Common Name:
Igbp1b-KO
Product ID:
S-KO-10196
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Igbp1b-KO
Strain ID
KOCMP-50540-Igbp1b-B6J-VA
Gene Name
Product ID
S-KO-10196
Gene Alias
alpha4-b
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
6
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Igbp1bem1/Cya mice (Catalog S-KO-10196) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000054786
NCBI RefSeq
NM_015777
Target Region
Exon 1
Size of Effective Region
~1.0 kb
Detailed Document
Overview of Gene Research
Igbp1b, also known as alpha4-b, is a gene encoding a protein that binds to the protein phosphatase 2A (PP2A). It plays a role in regulating phosphatase activity, likely within relevant cellular signal transduction pathways. The protein's function is crucial for normal physiological processes in specific tissues [1].
The alpha4-b (Igbp1b) transcript is selectively expressed in the brain and testis, not detected in the spleen, thymus, bone marrow, liver, kidney, lung, heart or muscle. In-situ RNA hybridization shows it is expressed in most neuronal cells in the brain but not in glial cells. The encoded protein is highly homologous (66% identity in amino-acid sequence) to the alpha4 molecule and associates with the catalytic subunit of PP2A (PP2Ac), suggesting its role in regulating phosphatase activity in neuronal cells [1].
In conclusion, Igbp1b is selectively expressed in the brain and testis and plays a role in regulating phosphatase activity in neuronal cells through its association with PP2Ac. Although no KO/CKO mouse model findings were presented, understanding its expression pattern and protein-protein interactions is fundamental for uncovering its role in normal brain and testicular function and potentially related diseases.
References:
1. Maeda, K, Inui, S, Tanaka, H, Sakaguchi, N. . A new member of the alpha4-related molecule (alpha4-b) that binds to the protein phosphatase 2A is expressed selectively in the brain and testis. In European journal of biochemistry, 264, 702-6. doi:. https://pubmed.ncbi.nlm.nih.gov/10491115/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen