C57BL/6JCya-Zfp622em1/Cya
Common Name:
Zfp622-KO
Product ID:
S-KO-10325
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Zfp622-KO
Strain ID
KOCMP-52521-Zfp622-B6J-VA
Gene Name
Product ID
S-KO-10325
Gene Alias
1110033B05Rik; D15Ertd806e; ZPR9; Znf622
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
15
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Zfp622em1/Cya mice (Catalog S-KO-10325) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000061875
NCBI RefSeq
NM_144523
Target Region
Exon 2~3
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Zfp622, also known as Zinc Finger Protein 622, has not had its essential function, associated pathways, or overall biological importance clearly detailed in the provided references. However, genetic models could potentially be valuable for further in-depth functional studies of this gene.
In one study, exploratory analyses in panic disorder patients suggested dynamic methylation of the ZFP622 gene along with response to cognitive-behavioral therapy (CBT), indicating its possible involvement in the epigenetic mechanisms related to panic disorder pathogenesis and treatment response [1]. In another study, ZFP622 was among the genes analyzed in Pekin duck breast muscle development. It had high expression levels at 6 weeks old, suggesting its possible role in breast muscle development in Pekin ducks [2].
In summary, while the exact biological functions of Zfp622 are yet to be fully elucidated, studies in panic disorder and Pekin duck breast muscle development suggest its potential significance in epigenetic mechanisms related to mental health treatment response and muscle development respectively. The use of genetic models like KO or CKO mouse models could further uncover its role in these and potentially other biological processes and disease conditions.
References:
1. Ziegler, Christiane, Grundner-Culemann, Franziska, Schiele, Miriam A, Köttgen, Anna, Domschke, Katharina. 2019. The DNA methylome in panic disorder: a case-control and longitudinal psychotherapy-epigenetic study. In Translational psychiatry, 9, 314. doi:10.1038/s41398-019-0648-6. https://pubmed.ncbi.nlm.nih.gov/31754096/
2. Xu, Tieshan, Huang, Wei, Zhang, Xiaohui, Zhou, Hanlin, Hou, Shuisheng. 2012. Identification and characterization of genes related to the development of breast muscles in Pekin duck. In Molecular biology reports, 39, 7647-55. doi:10.1007/s11033-012-1599-7. https://pubmed.ncbi.nlm.nih.gov/22451153/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen