C57BL/6JCya-Usp2em1/Cya
Common Name:
Usp2-KO
Product ID:
S-KO-10397
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Usp2-KO
Strain ID
KOCMP-53376-Usp2-B6J-VA
Gene Name
Product ID
S-KO-10397
Gene Alias
B930035K21Rik; Ubp41
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
9
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Usp2em1/Cya mice (Catalog S-KO-10397) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000034508
NCBI RefSeq
NM_198092
Target Region
Exon 3~4
Size of Effective Region
~2.1 kb
Detailed Document
Overview of Gene Research
Usp2, short for ubiquitin-specific processing protease 2, is a multifunctional deubiquitinating enzyme. It plays a significant role in multiple biological processes by modulating the stability of various proteins. Usp2 is involved in pathways such as cell cycle regulation, carcinogenesis, and immune response [2]. It can deubiquitinate proteins like cyclins, Aurora-A, and epidermal growth factor, influencing cell cycle progression and tumorigenesis [2].
In cancer, loss-of-function studies have shown multiple effects. Depletion of Usp2 in colorectal and prostate cancer cells leads to endoplasmic reticulum-associated degradation of PD-L1, enhancing T-cell-mediated killing and antitumor immunity in mice, suggesting its role in tumor immune evasion [1]. In gastric cancer, inhibiting the Usp2-E2F4 axis suppresses autophagic machinery essential for zinc homeostasis, reducing cancer cell growth, invasion, and metastasis [3]. In addition, in lung cancer, Usp2 may suppress the disease by reducing ARID2 protein degradation via ubiquitination [4].
In conclusion, Usp2 is a key deubiquitinating enzyme involved in various biological functions, especially in cancer-related processes. Gene knockout or knockdown studies in cancer cell lines and mouse models have revealed its roles in tumor immune evasion, autophagy regulation, and cancer cell invasion and migration, providing potential therapeutic targets for cancer treatment [1,3,4].
References:
1. Kuang, Zean, Liu, Xiaojia, Zhang, Na, Song, Danqing, Deng, Hongbin. 2023. USP2 promotes tumor immune evasion via deubiquitination and stabilization of PD-L1. In Cell death and differentiation, 30, 2249-2264. doi:10.1038/s41418-023-01219-9. https://pubmed.ncbi.nlm.nih.gov/37670038/
2. Kitamura, Hiroshi, Hashimoto, Mayuko. 2021. USP2-Related Cellular Signaling and Consequent Pathophysiological Outcomes. In International journal of molecular sciences, 22, . doi:10.3390/ijms22031209. https://pubmed.ncbi.nlm.nih.gov/33530560/
3. Xiao, Wenjing, Wang, Jianqun, Wang, Xiaojing, Tong, Qiangsong, Zheng, Liduan. 2022. Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression. In Autophagy, 18, 2615-2635. doi:10.1080/15548627.2022.2044651. https://pubmed.ncbi.nlm.nih.gov/35253629/
4. Zhu, Lihuan, Chen, Zhizhong, Guo, Tianxing, Guo, Lingwen, Pan, Xiaojie. 2022. USP2 Inhibits Lung Cancer Pathogenesis by Reducing ARID2 Protein Degradation via Ubiquitination. In BioMed research international, 2022, 1525216. doi:10.1155/2022/1525216. https://pubmed.ncbi.nlm.nih.gov/36567903/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen