C57BL/6JCya-Oip5os1em1/Cya
Common Name:
Oip5os1-KO
Product ID:
S-KO-11803
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Oip5os1-KO
Strain ID
KOCMP-66602-Oip5os1-B6J-VA
Gene Name
Product ID
S-KO-11803
Gene Alias
1190006L01Rik; 1700020I14Rik; 4933437I03Rik; Cyrano; Oip5as1; linc-oip5
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Oip5os1em1/Cya mice (Catalog S-KO-11803) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000147425
NCBI RefSeq
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Target Region
Exon 3
Size of Effective Region
~4.3 kb
Detailed Document
Overview of Gene Research
Oip5os1, also known as 1700020I14Rik, OIP5-AS1, and Cyrano, is a long non-coding RNA (lncRNA) [4]. It is broadly expressed across multiple tissues, with significant enrichment in the nervous system, skeletal muscle, and striated muscles [4]. It has regulatory functions in normal cellular processes such as cell proliferation and survival [4].
In a study of male mice, deletion of Oip5os1 in the setting of streptozotocin-induced diabetes led to left atrial dysfunction and myopathy, associated with anesthesia intolerance and premature death in most KO mice. There was a reduction in the metabolic regulator ERRalpha and a trend for a reduction in Serca2a in the atria of KO mice compared to WT mice, highlighting its role in atrial function in diabetes [1]. In CUMS-induced mice, geniposide regulated the Oip5os1/miR-25-3p/Gata2 network to alleviate depression-like behaviors [2]. Also, PFOS exposure downregulated Oip5os1 in pregnant mice, impairing trophoblast proliferation and migration via the Oip5os1/miR-155/Rnd3 axis, contributing to pre-eclampsia development [3].
In conclusion, Oip5os1 is a context-specific regulator involved in normal cellular processes like cell proliferation and survival. Gene knockout mouse models have revealed its importance in atrial function in diabetes, depression-like behaviors, and pre-eclampsia development, helping to understand the mechanisms of these disease conditions [1,2,3].
References:
1. Zhuang, Aowen, Tan, Yanie, Liu, Yingying, Calkin, Anna C, Drew, Brian G. . Deletion of the muscle enriched lncRNA Oip5os1 induces atrial dysfunction in male mice with diabetes. In Physiological reports, 11, e15869. doi:10.14814/phy2.15869. https://pubmed.ncbi.nlm.nih.gov/38054572/
2. Zhao, Yu, Zhang, Qian, Yan, Yuzhu, Mei, Cheng, Zou, Tianyu. 2022. Antidepressant-like effects of geniposide in chronic unpredictable mild stress-induced mice by regulating the circ_0008405/miR-25-3p/Gata2 and Oip5os1/miR-25-3p/Gata2 networks. In Phytotherapy research : PTR, 37, 1850-1863. doi:10.1002/ptr.7702. https://pubmed.ncbi.nlm.nih.gov/36515407/
3. Ye, Xiaomin, Zhong, Peiqu, Chen, Qiongfang, Zhang, Jiayuan, Zhao, Lijian. 2025. PFOS-Induced Perturbations in Trophoblast Functions through the Oip5os1/miR-155/Rnd3 Axis in PE. In Chemical research in toxicology, 38, 236-251. doi:10.1021/acs.chemrestox.4c00184. https://pubmed.ncbi.nlm.nih.gov/39807729/
4. Wooten, Serena, Smith, Keriayn N. . Long non-coding RNA OIP5-AS1 (Cyrano): A context-specific regulator of normal and disease processes. In Clinical and translational medicine, 12, e706. doi:10.1002/ctm2.706. https://pubmed.ncbi.nlm.nih.gov/35040588/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen