C57BL/6JCya-Isoc2bem1/Cya
Common Name
Isoc2b-KO
Product ID
S-KO-12276
Backgroud
C57BL/6JCya
Strain ID
KOCMP-67441-Isoc2b-B6J-VA
Status
When using this mouse strain in a publication, please cite “Isoc2b-KO Mouse (Catalog S-KO-12276) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Isoc2b-KO
Strain ID
KOCMP-67441-Isoc2b-B6J-VA
Gene Name
Product ID
S-KO-12276
Gene Alias
Isoc2, 0610042E07Rik
Background
C57BL/6JCya
Gene Full Name
isochorismatase domain containing 2b
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 7 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000064547
NCBI Transcript ID
NM_026158
Target Region
Exon 2~5
Size of Effective Region
~3.5 kb
Overview of Gene Research
Isoc2b is a gene that appears to be associated with energy production [1]. While its exact function and associated pathways are not comprehensively detailed in the given reference, the gene is mentioned among hypomethylated loci in aged mice. Hypomethylated regions around Isoc2b, along with other loci, were found to be associated with aging processes such as energy production [1].
The study compared age-and tissue-specific methylation differences in the brain and spleen of young and aged mice. Isoc2b was part of the loci with hypomethylation in aged mice, suggesting a possible role in the aging-related energy production processes [1].
In conclusion, Isoc2b seems to be involved in energy production processes, and its hypomethylation in aged mice implies a connection to the aging process. The study of Isoc2b in such age-related models provides insights into the role of methylation changes in genes like Isoc2b during the aging process, potentially contributing to our understanding of age-related metabolic and energy-related diseases [1].
References:
1. Uli, Nishanth, Michelen-Gomez, Eduardo, Ramos, Enrique I, Druley, Todd E. 2018. Age-specific changes in genome-wide methylation enrich for Foxa2 and estrogen receptor alpha binding sites. In PloS one, 13, e0203147. doi:10.1371/journal.pone.0203147. https://pubmed.ncbi.nlm.nih.gov/30256791/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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