Lce1f, a member of the Late Cornified Envelope Group I (LCE1) genes, is located in the LCE gene clusters encoding stratum-corneum proteins. It is a novel downstream target of p53, a crucial tumor suppressor gene. Lce1f likely has tumor suppressor functions through modulating the activity of protein arginine methyltransferase 5 (PRMT5), and may also be involved in DNA damage response as its expression level changes with UVC radiation dose in human lymphocytes [2,3].

In a bioinformatics study on the cross-talk between periodontitis (PD) and hypothyroidism (HT), Lce1f was among the top 10 genes with the most connections in the Protein-Protein Interaction (PPI) network. This indicates its potential importance in the genetic cross-talk between these two conditions. However, no gene knockout or conditional knockout mouse model-related findings were presented in the references [1].

In summary, Lce1f is an important gene with potential tumor-suppressing functions via PRMT5 modulation and possible involvement in DNA damage response. Its role in the genetic cross-talk between PD and HT also shows its significance in disease-related genetic mechanisms, despite the lack of evidence from KO/CKO mouse models in the provided references.

References:

1. Yan, Bin, Ren, Fukai, Shang, Wei, Gong, Xiaoyan. 2022. Transcriptomic Analysis Reveals Genetic Cross-Talk between Periodontitis and Hypothyroidism. In Disease markers, 2022, 5736394. doi:10.1155/2022/5736394. https://pubmed.ncbi.nlm.nih.gov/35450027/

2. Deng, Zhenzhong, Matsuda, Koichi, Tanikawa, Chizu, Hamamoto, Ryuji, Nakamura, Yusuke. . Late Cornified Envelope Group I, a novel target of p53, regulates PRMT5 activity. In Neoplasia (New York, N.Y.), 16, 656-64. doi:10.1016/j.neo.2014.07.008. https://pubmed.ncbi.nlm.nih.gov/25220593/

3. Xu, Dan, Wang, Yue, Wang, Jia, Qi, Fei, Sun, Yeqing. 2020. The Potential Regulatory Roles of lncRNAs in DNA Damage Response in Human Lymphocytes Exposed to UVC Irradiation. In BioMed research international, 2020, 8962635. doi:10.1155/2020/8962635. https://pubmed.ncbi.nlm.nih.gov/32258156/