C57BL/6NCya-Fam114a1em1/Cya
Common Name
Fam114a1-KO
Product ID
S-KO-12681
Backgroud
C57BL/6NCya
Strain ID
KOCMP-68303-Fam114a1-B6N-VA
Status
When using this mouse strain in a publication, please cite “Fam114a1-KO Mouse (Catalog S-KO-12681) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Fam114a1-KO
Strain ID
KOCMP-68303-Fam114a1-B6N-VA
Gene Name
Product ID
S-KO-12681
Gene Alias
1190001N04Rik, 9130005N14Rik, Noxp20
Background
C57BL/6NCya
Gene Full Name
--
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 5 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000031080
NCBI Transcript ID
NM_026667
Target Region
Exon 4~7
Size of Effective Region
~10.7 kb
Overview of Gene Research
Fam114a1, Family with sequence similarity 114 member A1, is involved in multiple biological functions. It has been linked to pathways such as angiotensin II signaling, and is of importance in various biological processes and diseases [1]. Genetic models, like KO mouse models, have been valuable in studying its role.
In KO mouse models, homozygous KO of Fam114a1 reduces cardiomyocyte hypertrophy, inflammation, and cardiac fibrosis, while restoring cardiac function in angiotensin II-induced and MI-induced heart failure mouse models. This indicates its role in regulating angiotensin II signaling, activating cardiac fibroblasts and other cardiac cells, and augmenting pathological cardiac remodeling [1]. In melanocytes, inhibition of Fam114a1 increases proliferation, migration, and melanin synthesis proteins, and decreases apoptosis, through negatively regulating RACK1 [2]. In hepatocellular carcinoma cells, suppression of Fam114a1 reduces cell proliferation and migration by modulating AKT1, promotes apoptosis, arrests the cell cycle, and inhibits epithelial-mesenchymal transition (EMT) [3].
In summary, Fam114a1 plays diverse roles in different biological processes. Its study using KO mouse models has provided insights into its functions in cardiac pathological remodeling, melanocyte function, and hepatocellular carcinoma development, highlighting its potential as a therapeutic target in related diseases [1-3].
References:
1. Subbaiah, Kadiam C Venkata, Wu, Jiangbin, Tang, Wai Hong Wilson, Yao, Peng. 2022. FAM114A1 influences cardiac pathological remodeling by regulating angiotensin II signaling. In JCI insight, 7, . doi:10.1172/jci.insight.152783. https://pubmed.ncbi.nlm.nih.gov/35671117/
2. Zhou, Miaoni, Lin, Fuquan, Wu, Xingang, Jin, Rong, Xu, Aie. 2021. Inhibition of Fam114A1 protects melanocytes from apoptosis through higher RACK1 expression. In Aging, 13, 24740-24752. doi:10.18632/aging.203712. https://pubmed.ncbi.nlm.nih.gov/34837888/
3. Zhang, Haifeng, Zeng, Yu, Ye, Chihua, Cai, Jianwu, Hu, Xiao. . Inhibition of FAM114A1 Suppresses Hepatocellular Carcinoma by Targeting AKT1 Signaling. In Annals of clinical and laboratory science, 54, 378-387. doi:. https://pubmed.ncbi.nlm.nih.gov/39048162/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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