C57BL/6JCya-Tektl1em1/Cya
Common Name
Tektl1-KO
Product ID
S-KO-13476
Backgroud
C57BL/6JCya
Strain ID
KOCMP-70976-Tektl1-B6J-VA
When using this mouse strain in a publication, please cite “Tektl1-KO Mouse (Catalog S-KO-13476) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Tektl1-KO
Strain ID
KOCMP-70976-Tektl1-B6J-VA
Gene Name
Product ID
S-KO-13476
Gene Alias
4931413A09Rik, Ccdc105
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 10
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000105383
NCBI RefSeq
NM_027630
Target Region
Exon 1
Size of Effective Region
~0.7 kb
Overview of Gene Research
Tektl1 is a gene enriched in male reproductive tissues. However, its exact function, associated pathways, and key aliases remain unknown. Genetic models, such as knockout mouse models, are valuable tools to explore its gene function [1].
A study using the CRISPR/Cas9 system to generate gene-deficient mice found that Tektl1-deficient mice exhibited normal fertility in natural breeding experiments. This indicates that Tektl1 is not essential for male fertility [1].
In conclusion, through the use of KO mouse models, it has been revealed that Tektl1, despite its enrichment in male reproductive tissues, is dispensable for male fertility. This finding helps in the efficient allocation of research resources in the study of male reproductive biology, preventing duplication of efforts to generate knockout mice for genes without an apparent male-fertility-related phenotype [1].
References:
1. Nguyen, Tuyen Thi Thanh, Tokuhiro, Keizo, Shimada, Keisuke, Kiyozumi, Daiji, Ikawa, Masahito. 2024. Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. In Frontiers in cell and developmental biology, 12, 1411162. doi:10.3389/fcell.2024.1411162. https://pubmed.ncbi.nlm.nih.gov/38835510/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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