Ms4a6c, though specific aliases aren't mentioned in the provided references, seems to be involved in the myeloid cell-related processes in the central nervous system (CNS). In the context of CNS myeloid cells, it is part of a monocyte signature where its up-regulation was observed when there was long-term and brain-wide engraftment of peripheral bone marrow-derived myeloid cells in the brain parenchyma [1]. Also, in experimental autoimmune encephalomyelitis (EAE) mice, the mRNA expression of Ms4a6c was increased at the high clinical score (HCS) of the disease [2].

In the CNS, the long-term engraftment of monocytes, with Ms4a6c being part of their signature, induced brain region-dependent alterations in transcription profiles, astrocytes, neuronal structures, and cognition [1]. In EAE mice, Herceptin treatment reduced the increased mRNA levels of Ms4a6c (except for Cd74 and Clec7a) at HCS, suggesting its role in the disease-related molecular changes [2].

In conclusion, Ms4a6c is associated with myeloid cell-related activities in the CNS, being part of monocyte signatures during specific engraftment processes and showing differential expression in EAE mice. Its study, potentially through gene knockout models in the future, could further clarify its role in CNS-related diseases like EAE and in understanding the complex regulation of myeloid cells in the brain.

References:

1. Hohsfield, Lindsay A, Najafi, Allison R, Ghorbanian, Yasamine, Inlay, Mathew A, Green, Kim N. 2020. Effects of long-term and brain-wide colonization of peripheral bone marrow-derived myeloid cells in the CNS. In Journal of neuroinflammation, 17, 279. doi:10.1186/s12974-020-01931-0. https://pubmed.ncbi.nlm.nih.gov/32951604/

2. Al-Ani, Mena, Elemam, Noha Mousaad, Hachim, Ibrahim Y, Bendardaf, Riyad, Maghazachi, Azzam A. 2021. Molecular Examination of Differentially Expressed Genes in the Brains of Experimental Autoimmune Encephalomyelitis Mice Post Herceptin Treatment. In Journal of inflammation research, 14, 2601-2617. doi:10.2147/JIR.S310535. https://pubmed.ncbi.nlm.nih.gov/34168483/