C57BL/6JCya-Garin5aem1/Cya
Common Name
Garin5a-KO
Product ID
S-KO-14659
Backgroud
C57BL/6JCya
Strain ID
KOCMP-75538-Garin5a-B6J-VA
When using this mouse strain in a publication, please cite “Garin5a-KO Mouse (Catalog S-KO-14659) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Garin5a-KO
Strain ID
KOCMP-75538-Garin5a-B6J-VA
Gene Name
Product ID
S-KO-14659
Gene Alias
0610007G24Rik, 1700021N13Rik, 1700021P22Rik, Fam71e1, GARI-L5, GARIL5
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000107927
NCBI RefSeq
NM_028169
Target Region
Exon 4
Size of Effective Region
~0.3 kb
Overview of Gene Research
Garin5a, a member of the Golgi Associated RAB2 Interactors (GARINs; also known as FAM71) protein family, has a RAB2-binding domain. The GARINs family is mainly expressed in the testis, and RAB2 is involved in membrane transport and vesicle trafficking. Understanding Garin5a's function is crucial, and genetic models like KO mouse models are valuable for its study [1].
In KO mouse models, the loss of Garin5a led to aberrant sperm head morphogenesis. Garin5a-/-males were found to be subfertile, indicating that Garin5a is important for normal sperm head development and male fertility [1].
In conclusion, through KO mouse model-based research, Garin5a has been shown to play an essential role in assuring correct sperm head morphogenesis and male fertility. The study of Garin5a KO mice contributes to understanding the molecular mechanisms underlying male infertility [1].
References:
1. Wang, Haoting, Iida-Norita, Rie, Mashiko, Daisuke, Miyata, Haruhiko, Ikawa, Masahito. 2024. Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads. In PLoS genetics, 20, e1011337. doi:10.1371/journal.pgen.1011337. https://pubmed.ncbi.nlm.nih.gov/38935810/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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