C57BL/6JCya-Ttc23lem1/Cya
Common Name:
Ttc23l-KO
Product ID:
S-KO-14743
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Ttc23l-KO
Strain ID
KOCMP-75777-Ttc23l-B6J-VA
Gene Name
Product ID
S-KO-14743
Gene Alias
4930401A09Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
15
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ttc23lem1/Cya mice (Catalog S-KO-14743) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000022857
NCBI RefSeq
NM_029430
Target Region
Exon 2~6
Size of Effective Region
~18.0 kb
Detailed Document
Overview of Gene Research
Ttc23l, a gene of significance, is likely involved in various biological processes. However, specific details about its aliases, essential functions, associated pathways are not elaborated in the provided references. But genes with which it was co-detected in a study were related to immune system, stress response, reproduction, embryo development, and carbohydrate and lipid metabolism, hinting at its potential role in similar processes [1].
In a study on rabbits selected for environmental variance of litter size, Ttc23l was among the genes with functional mutations. A functional mutation in Ttc23l was fixed in one rabbit line and absent in the other, suggesting its possible role in controlling the environmental variance of litter size and potentially animal resilience. However, functional analyses are needed to fully assess its implications [1].
In conclusion, Ttc23l may play a role in processes related to the environment-related variance of litter size and animal resilience in rabbits, as indicated by the presence of a fixed functional mutation in one of the divergent rabbit lines. Further functional studies are required to fully understand its biological functions and its potential contribution to these and other related areas.
References:
1. Casto-Rebollo, Cristina, Argente, María José, García, María Luz, Blasco, Agustín, Ibáñez-Escriche, Noelia. 2021. Selection for environmental variance of litter size in rabbits involves genes in pathways controlling animal resilience. In Genetics, selection, evolution : GSE, 53, 59. doi:10.1186/s12711-021-00653-y. https://pubmed.ncbi.nlm.nih.gov/34256696/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen