C57BL/6JCya-Il24em1/Cya
Common Name
Il24-KO
Product ID
S-KO-15440
Backgroud
C57BL/6JCya
Strain ID
KOCMP-93672-Il24-B6J-VA
When using this mouse strain in a publication, please cite “Il24-KO Mouse (Catalog S-KO-15440) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Il24-KO
Strain ID
KOCMP-93672-Il24-B6J-VA
Gene Name
Product ID
S-KO-15440
Gene Alias
FISP, If2e, Mda-7, Mda7, St16
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 1
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000121040
NCBI RefSeq
NM_053095
Target Region
Exon 2~5
Size of Effective Region
~3.2 kb
Overview of Gene Research
IL24, also known as melanoma differentiation-associated gene-7 (MDA-7), is a cytokine belonging to the IL-10 family. It has diverse functions, playing roles in maintaining tissue epithelial layer integrity and homeostasis, and is involved in host defense mechanisms, especially in responses from epithelial cells during infections [1]. It also contributes to the tissue-healing process after injury caused by infection or inflammation.
In mouse models, Il24 ablation impedes epidermal proliferation, re-epithelialization, capillary and fibroblast regeneration within the dermal wound bed, indicating its crucial role in tissue repair [2]. In the context of idiopathic pulmonary fibrosis, IL24 deficiency protects mice from bleomycin-induced lung injury and fibrosis by attenuating TGF-β1 production and reducing M2 macrophage infiltration, suggesting its involvement in promoting pulmonary fibrosis development [3].
In conclusion, IL24 is essential for tissue repair and homeostasis. Gene-knockout mouse models have revealed its roles in tissue repair processes and in disease conditions such as pulmonary fibrosis. Understanding IL24's functions through these models provides insights into potential therapeutic targets for related diseases.
References:
1. Ouyang, Wenjun, Rutz, Sascha, Crellin, Natasha K, Valdez, Patricia A, Hymowitz, Sarah G. . Regulation and functions of the IL-10 family of cytokines in inflammation and disease. In Annual review of immunology, 29, 71-109. doi:10.1146/annurev-immunol-031210-101312. https://pubmed.ncbi.nlm.nih.gov/21166540/
2. Liu, Siqi, Hur, Yun Ha, Cai, Xin, Mucida, Daniel, Fuchs, Elaine. 2023. A tissue injury sensing and repair pathway distinct from host pathogen defense. In Cell, 186, 2127-2143.e22. doi:10.1016/j.cell.2023.03.031. https://pubmed.ncbi.nlm.nih.gov/37098344/
3. Rao, Li-Zong, Wang, Yi, Zhang, Lei, Wang, Cong-Yi, Zhang, Huilan. 2020. IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages. In Cell death and differentiation, 28, 1270-1283. doi:10.1038/s41418-020-00650-6. https://pubmed.ncbi.nlm.nih.gov/33144678/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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