C57BL/6NCya-Camk1dem1/Cya
Common Name
Camk1d-KO
Product ID
S-KO-16170
Backgroud
C57BL/6NCya
Strain ID
KOCMP-227541-Camk1d-B6N-VC
When using this mouse strain in a publication, please cite “Camk1d-KO Mouse (Catalog S-KO-16170) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Camk1d-KO
Strain ID
KOCMP-227541-Camk1d-B6N-VC
Gene Name
Product ID
S-KO-16170
Gene Alias
A630059D12Rik, CKLiK, CaMKIdelta, E030025C11Rik, mCKLiK
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 2
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000044009
NCBI RefSeq
NM_177343
Target Region
Exon 4~5
Size of Effective Region
~7.5 kb
Overview of Gene Research
Camk1d, or calcium/calmodulin-dependent protein kinase ID, is involved in multiple intracellular signaling pathways and is of great biological importance. It has been linked to pathways such as the PI3K/AKT/mTOR pathway and is associated with various biological processes and diseases [2].
Global Camk1d-knockout male mice are resistant to ghrelin, gain less body weight, and are protected against high-fat-diet-induced obesity. Deletion of Camk1d in AgRP/NPY neurons recapitulates these phenotypes, indicating its role in ghrelin-mediated food intake [1]. In glioma, knockdown of Camk1D promotes the proliferation, invasion, and migration of glioma cells, suggesting it inhibits glioma through the PI3K/AKT/mTOR pathway [2].
In conclusion, Camk1d is crucial in regulating food intake via its action in AgRP/NPY neurons in response to ghrelin. In addition, it plays a role in inhibiting glioma cell growth. The gene knockout mouse models have been instrumental in revealing these functions, providing insights into potential therapeutic targets for obesity-related diseases and glioma.
References:
1. Vivot, Karl, Meszaros, Gergö, Pangou, Evanthia, Nogueiras, Ruben, Ricci, Romeo. 2023. CaMK1D signalling in AgRP neurons promotes ghrelin-mediated food intake. In Nature metabolism, 5, 1045-1058. doi:10.1038/s42255-023-00814-x. https://pubmed.ncbi.nlm.nih.gov/37277610/
2. Jin, Qianxu, Zhao, Jiahui, Zhao, Zijun, Liu, Liping, Zhao, Zongmao. 2022. CAMK1D Inhibits Glioma Through the PI3K/AKT/mTOR Signaling Pathway. In Frontiers in oncology, 12, 845036. doi:10.3389/fonc.2022.845036. https://pubmed.ncbi.nlm.nih.gov/35494053/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.