Camk1d, or calcium/calmodulin-dependent protein kinase ID, is involved in multiple intracellular signaling pathways and is of great biological importance. It has been linked to pathways such as the PI3K/AKT/mTOR pathway and is associated with various biological processes and diseases [2].

Global Camk1d-knockout male mice are resistant to ghrelin, gain less body weight, and are protected against high-fat-diet-induced obesity. Deletion of Camk1d in AgRP/NPY neurons recapitulates these phenotypes, indicating its role in ghrelin-mediated food intake [1]. In glioma, knockdown of Camk1D promotes the proliferation, invasion, and migration of glioma cells, suggesting it inhibits glioma through the PI3K/AKT/mTOR pathway [2].

In conclusion, Camk1d is crucial in regulating food intake via its action in AgRP/NPY neurons in response to ghrelin. In addition, it plays a role in inhibiting glioma cell growth. The gene knockout mouse models have been instrumental in revealing these functions, providing insights into potential therapeutic targets for obesity-related diseases and glioma.

References:

1. Vivot, Karl, Meszaros, Gergö, Pangou, Evanthia, Nogueiras, Ruben, Ricci, Romeo. 2023. CaMK1D signalling in AgRP neurons promotes ghrelin-mediated food intake. In Nature metabolism, 5, 1045-1058. doi:10.1038/s42255-023-00814-x. https://pubmed.ncbi.nlm.nih.gov/37277610/

2. Jin, Qianxu, Zhao, Jiahui, Zhao, Zijun, Liu, Liping, Zhao, Zongmao. 2022. CAMK1D Inhibits Glioma Through the PI3K/AKT/mTOR Signaling Pathway. In Frontiers in oncology, 12, 845036. doi:10.3389/fonc.2022.845036. https://pubmed.ncbi.nlm.nih.gov/35494053/