Ccdc27, whose full name is Coiled-Coil Domain Containing 27, is currently considered as a positional candidate gene. Its exact function, associated pathways, and overall biological importance are yet to be fully elucidated, but genetic models could be valuable for further study.

A study analyzing a high-density SNP panel on chromosome 1p36 for linkage and association to bone mineral density (BMD) in 39 osteoporosis pedigrees found that Ccdc27 is among the candidate genes potentially associated with BMD. The study identified a SNP within Ccdc27 with p < 0.001 for at least one BMD trait, suggesting its possible role in the genetic risk factors for low BMD [1].

In conclusion, although the exact biological functions of Ccdc27 are not comprehensively understood, the study indicates its potential significance in the context of BMD-related genetic factors. The finding from this research provides a starting point for further in-vivo studies, such as gene knockout or conditional knockout mouse models, to explore how Ccdc27 might contribute to the regulation of BMD and potentially related bone-related diseases.

References:

1. Zhang, H, Sol-Church, K, Rydbeck, H, Spotila, L D, Devoto, M. 2008. High resolution linkage and linkage disequilibrium analyses of chromosome 1p36 SNPs identify new positional candidate genes for low bone mineral density. In Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 20, 341-6. doi:10.1007/s00198-008-0668-1. https://pubmed.ncbi.nlm.nih.gov/18597038/