Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Slc22a2em1/Cya
Common Name:
Slc22a2-KO
Product ID:
S-KO-17023
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Slc22a2-KO
Strain ID
KOCMP-20518-Slc22a2-B6J-VA
Gene Name
Slc22a2
Product ID
S-KO-17023
Gene Alias
Oct2; Orct2; mOCT2
Background
C57BL/6JCya
NCBI ID
20518
Modification
Conventional knockout
Chromosome
17
Phenotype
MGI:1335072
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc22a2em1/Cya mice (Catalog S-KO-17023) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000046959
NCBI RefSeq
NM_013667
Target Region
Exon 2
Size of Effective Region
~0.6 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Slc22a2, encoding the organic cation transporter-2 (OCT2), is a member of the SLC22 transporter family. It mediates the electrogenic transport of small organic cations with different molecular structures, playing a role in the uptake, pharmacological effects, and/or adverse effects of many cationic clinical therapeutics and xenobiotics [3,7]. It is also involved in key metabolic pathways and levels of signaling molecules, and is responsible for about 80% of the total metformin clearance [3,4].

In patients with colorectal cancer receiving oxaliplatin chemotherapy, the rs316019 genotype of Slc22a2 was significantly associated with the severity of leucopenia and neutropenia, and the rs1869641 genotype was associated with the occurrence of thrombocytopenia [1]. In HIV-positive patients treated with dolutegravir, the SLC22A2 CA genotype was associated with abnormal general severity index, anxiety, hostility, and moderate to severe headache [2]. Variants in Slc22a2 were associated with phenotypes of net tubular creatinine secretion and end-stage renal disease in renal transplant recipients [5]. Also, the SLC22A2 808G/G genotype, among other factors, influenced the change rate of creatinine in chronic myeloid leukemia patients taking bosutinib [6].

In conclusion, Slc22a2 is crucial for drug transport and metabolic regulation. Studies on its genetic polymorphisms in various patient populations have revealed its associations with drug-related hematological toxicities, psychiatric symptoms, creatinine-related phenotypes, and more. These findings contribute to understanding the role of Slc22a2 in different disease conditions and drug responses.

References:

1. Chen, Jiayin, Wang, Li, Tong, Gangling, Liu, Chaoran, Wang, Lijun. . The SLC22A2 gene is a determinant of hematological toxicity of oxaliplatin in patients with colorectal cancer. In International journal of clinical pharmacology and therapeutics, 61, 1-7. doi:10.5414/CP204156. https://pubmed.ncbi.nlm.nih.gov/36331012/

2. Borghetti, A, Calcagno, A, Lombardi, F, Bonora, S, Di Giambenedetto, S. . SLC22A2 variants and dolutegravir levels correlate with psychiatric symptoms in persons with HIV. In The Journal of antimicrobial chemotherapy, 74, 1035-1043. doi:10.1093/jac/dky508. https://pubmed.ncbi.nlm.nih.gov/30561642/

3. Pearce, Brendon, Jacobs, Clifford, Hoosain, Nisreen, Benjeddou, Mongi. . SLC22A2 - mapping genomic variations within South African indigenous and admixed populations. In Drug metabolism and personalized therapy, 31, 213-220. doi:10.1515/dmpt-2016-0022. https://pubmed.ncbi.nlm.nih.gov/27828777/

4. Nigam, Sanjay K. . The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease. In Annual review of pharmacology and toxicology, 58, 663-687. doi:10.1146/annurev-pharmtox-010617-052713. https://pubmed.ncbi.nlm.nih.gov/29309257/

5. Reznichenko, Anna, Sinkeler, Steef J, Snieder, Harold, Seelen, Marc, Navis, Gerjan. 2013. SLC22A2 is associated with tubular creatinine secretion and bias of estimated GFR in renal transplantation. In Physiological genomics, 45, 201-9. doi:10.1152/physiolgenomics.00087.2012. https://pubmed.ncbi.nlm.nih.gov/23341218/

6. Abumiya, Maiko, Takahashi, Naoto, Takahashi, Saori, Kameoka, Yoshihiro, Miura, Masatomo. 2021. Effects of SLC22A2 808G>T polymorphism and bosutinib concentrations on serum creatinine in patients with chronic myeloid leukemia receiving bosutinib therapy. In Scientific reports, 11, 6362. doi:10.1038/s41598-021-85757-7. https://pubmed.ncbi.nlm.nih.gov/33737618/

7. Jacobs, Clifford, Pearce, Brendon, Du Plessis, Mornè, Hoosain, Nisreen, Benjeddou, Mongi. 2015. Single nucleotide polymorphisms of the SLC22A2 gene within the Xhosa population of South Africa. In Drug metabolism and pharmacokinetics, 30, 457-60. doi:10.1016/j.dmpk.2015.11.002. https://pubmed.ncbi.nlm.nih.gov/26674735/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest