C57BL/6JCya-Krt87em1/Cya
Common Name:
Krt87-KO
Product ID:
S-KO-17151
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Krt87-KO
Strain ID
KOCMP-406219-Krt87-B6J-VA
Gene Name
Product ID
S-KO-17151
Gene Alias
K83; K87; Krt2-25; Krt83
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
15
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Krt87em1/Cya mice (Catalog S-KO-17151) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000081945
NCBI RefSeq
NM_001003668.2
Target Region
Exon 2
Size of Effective Region
~1.1 kb
Detailed Document
Overview of Gene Research
Krt87, a keratin intermediate filament gene, is involved in the composition of wool and hair proteins. Keratin intermediate filaments play crucial roles in maintaining cell structure and integrity. The discovery of type II Krt87 in sheep exemplifies species-specific compositional differences in hair KRT genes [2].
In male Wistar rats, an acute stress exposure led to a strong increase in the expression of intermediate filaments including Krt87. This indicates its potential role in the body's response to acute stress, perhaps in maintaining cellular integrity during such challenging conditions [1].
In summary, Krt87 is important for the structure of wool and hair in sheep, and its increased expression in stressed rats suggests a role in the stress response, potentially in preserving cell structure. These findings from different research models help understand the gene's functions in normal and stress-related biological processes.
References:
1. Lanshakov, Dmitriy A, Sukhareva, Ekaterina V, Bulygina, Veta V, Denisov, Evgeny V, Kalinina, Tatyana S. 2024. Brainstem transcriptomic changes in male Wistar rats after acute stress, comparing the use of duplex specific nuclease (DSN). In Scientific reports, 14, 21856. doi:10.1038/s41598-024-73042-2. https://pubmed.ncbi.nlm.nih.gov/39300279/
2. Yu, Zhidong, Wildermoth, Janet E, Wallace, Olivia A M, Nixon, Allan J, Pearson, Allan J. 2011. Annotation of sheep keratin intermediate filament genes and their patterns of expression. In Experimental dermatology, 20, 582-8. doi:10.1111/j.1600-0625.2011.01274.x. https://pubmed.ncbi.nlm.nih.gov/21554405/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen