C57BL/6JCya-Slc22a4em1/Cya
Common Name
Slc22a4-KO
Product ID
S-KO-17293
Backgroud
C57BL/6JCya
Strain ID
KOCMP-30805-Slc22a4-B6J-VB
When using this mouse strain in a publication, please cite “Slc22a4-KO Mouse (Catalog S-KO-17293) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Slc22a4-KO
Strain ID
KOCMP-30805-Slc22a4-B6J-VB
Gene Name
Product ID
S-KO-17293
Gene Alias
Octn1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 11
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000020586
NCBI RefSeq
NM_019687.4
Target Region
Exon 2
Size of Effective Region
~1.3 kb
Overview of Gene Research
Slc22a4, also known as OCTN1, is an organic cation transporter. It plays a crucial role in the absorption and distribution of ergothioneine (ERGO), a food-derived antioxidant. ERGO is hydrophilic, and its entry into various organs, including the brain, is mediated by Slc22a4. This transporter is also involved in the renal reabsorption of ergothioneine [1,2,3].
In Octn1 gene knockout mice, ERGO is absent in the brain due to the lack of OCTN1 in neurons, neural stem cells, and microglia. This indicates that Slc22a4-mediated ERGO uptake is vital for brain function. Oral administration of ERGO shows antidepressant activities in mice, and repeated oral intake of ERGO or ERGO-containing food extract tablets enhances memory function in mice and humans, respectively. Also, ERGO protects against stress-induced sleep disturbance and neuronal injury induced by amyloid β in rodents [1].
In conclusion, Slc22a4 is essential for the distribution of ergothioneine, especially in the brain. The study of Octn1 gene knockout mice has revealed its role in maintaining brain function, such as in promoting memory and protecting against neuronal injury. This suggests its potential significance in treating neurological disorders related to oxidative stress and neurodegeneration [1].
References：
1. Ishimoto, Takahiro, Kato, Yukio. 2022. Ergothioneine in the brain. In FEBS letters, 596, 1290-1298. doi:10.1002/1873-3468.14271. https://pubmed.ncbi.nlm.nih.gov/34978075/
2. Borodina, Irina, Kenny, Louise C, McCarthy, Cathal M, van der Hoek, Steven A, Kell, Douglas B. 2020. The biology of ergothioneine, an antioxidant nutraceutical. In Nutrition research reviews, 33, 190-217. doi:10.1017/S0954422419000301. https://pubmed.ncbi.nlm.nih.gov/32051057/
3. Tian, Xiaoying, Thorne, James L, Moore, J Bernadette. . Ergothioneine: an underrecognised dietary micronutrient required for healthy ageing? In The British journal of nutrition, 129, 104-114. doi:10.1017/S0007114522003592. https://pubmed.ncbi.nlm.nih.gov/38018890/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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