Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Tacr3em1/Cya
Common Name:
Tacr3-KO
Product ID:
S-KO-17612
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Tacr3-KO
Strain ID
KOCMP-21338-Tacr3-B6J-VB
Gene Name
Tacr3
Product ID
S-KO-17612
Gene Alias
Nk3r; Nkr; Tac3r
Background
C57BL/6JCya
NCBI ID
21338
Modification
Conventional knockout
Chromosome
3
Phenotype
MGI:892968
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tacr3em1/Cya mice (Catalog S-KO-17612) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000029822
NCBI RefSeq
NM_021382
Target Region
Exon 3
Size of Effective Region
~0.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Tacr3 encodes tachykinin receptor 3 (NK3R), belonging to the tachykinin receptor family within the rhodopsin subfamily of G protein-coupled receptors. It functions by binding to its high-affinity ligand, neurokinin B (NKB), and is involved in the neuroendocrine control of GnRH release, playing a significant role in growth and reproduction. Also, it is widely expressed in the nervous system from the spinal cord to the brain, participating in numerous physiological and pathological nervous system processes [1].

In a mouse model of trigeminal neuralgia, Tacr3 in the lateral habenula was found to play a protective role. Down-regulation of Tacr3 was observed in the lateral habenula of mice with orofacial allodynia and anxiety-like behaviors induced by partial transection of the infraorbital nerve. Rescuing this down-regulation by overexpressing Tacr3 significantly reversed the anxiety-like behaviors but not allodynia. Bilateral Tacr3 overexpression or chemicogenetic inhibition of bilateral lateral habenula neurons alleviated both allodynia and anxiety-like behaviors, suggesting that Tacr3 suppresses the hyperexcitability of lateral habenula neurons [3]. In rats, severe anxiety is linked to dampened TACR3 expression in the ventral hippocampus. TACR3 expression is sensitive to sex hormones, and its modulation significantly influences synaptic activity. Deficient TACR3 activity leads to lower serum testosterone levels, increased spine density, and impaired long-term potentiation in the dentate gyrus [2]. Mutations in TACR3 can disrupt NK3R function through distinct mechanisms. For example, certain mutations in the fifth and sixth transmembrane domains result in reduced whole-cell or plasma membrane levels of the receptor, nearly completely losing inositol phosphate signaling, while a mutation in the third intracellular loop impairs dissociation of Gq-protein subunits from the receptor [4]. Compound heterozygous mutations in TACR3 in siblings were associated with normosmic congenital hypogonadotropic hypogonadism [5].

In conclusion, Tacr3 plays crucial roles in both reproductive and nervous system-related biological processes. Research using mouse models has revealed its significance in conditions such as trigeminal neuralgia-associated mood disorders, anxiety-related synaptic plasticity, and reproductive disorders like hypogonadotropic hypogonadism. Understanding Tacr3 can provide insights into the underlying mechanisms of these diseases and potentially lead to new therapeutic strategies.

References:
1. Zhang, Wen-Wen, Wang, Yanqing, Chu, Yu-Xia. 2020. Tacr3/NK3R: Beyond Their Roles in Reproduction. In ACS chemical neuroscience, 11, 2935-2943. doi:10.1021/acschemneuro.0c00421. https://pubmed.ncbi.nlm.nih.gov/32926772/
2. Wojtas, Magdalena Natalia, Diaz-González, Marta, Stavtseva, Nadezhda, Veksler-Lublinsky, Isana, Knafo, Shira. 2023. Interplay between hippocampal TACR3 and systemic testosterone in regulating anxiety-associated synaptic plasticity. In Molecular psychiatry, 29, 686-703. doi:10.1038/s41380-023-02361-z. https://pubmed.ncbi.nlm.nih.gov/38135756/
3. Cui, Wen-Qiang, Zhang, Wen-Wen, Chen, Teng, Wang, Yan-Qing, Chu, Yu-Xia. 2020. Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia. In Acta neuropathologica communications, 8, 44. doi:10.1186/s40478-020-00922-9. https://pubmed.ncbi.nlm.nih.gov/32264959/
4. Noel, Sekoni D, Abreu, Ana Paula, Xu, Shuyun, Carroll, Rona S, Kaiser, Ursula B. 2013. TACR3 mutations disrupt NK3R function through distinct mechanisms in GnRH-deficient patients. In FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28, 1924-37. doi:10.1096/fj.13-240630. https://pubmed.ncbi.nlm.nih.gov/24376026/
5. Valsassina, Rita, Briosa, Filipa, Soares, Joana, Amorim, Marta, Limbert, Catarina. 2020. Hypogonadotropic hypogonadism due to compound heterozygous mutations TACR3 in siblings. In Clinical case reports, 8, 3126-3129. doi:10.1002/ccr3.3370. https://pubmed.ncbi.nlm.nih.gov/33363893/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest