Fam167b, a member of the FAM167 gene family, along with Fam167a, encodes a protein denoted DIORA-2. The FAM167 gene family is evolutionarily conserved and not homologous to other annotated genes. The proteins encoded by this family are characterized by a high content of intrinsic disorder [1].

The reference explores the FAM167 gene family in relation to rheumatic diseases. While the focus was more on Fam167a, it was found that the autoimmune risk genotypes within the FAM167A-BLK locus lead to increased expression of Fam167a. Both Fam167a and Fam167b are conserved, and the encoded proteins DIORA-1 and DIORA-2 have high intrinsic disorder. DIORA-1, encoded by Fam167a, has high expression in the lung, in bronchial epithelium and alveolar macrophages [1].

In conclusion, Fam167b, as part of the FAM167 gene family, encodes a protein with high intrinsic disorder. Although the reference didn't directly study Fam167b in KO/CKO mouse models, the knowledge of its conservation and protein characteristics provides a basis for further functional studies. The association of the FAM167A-BLK locus with rheumatic diseases implies a potential role for Fam167b in these disease processes, warranting future in-vivo studies such as the use of KO or CKO mouse models to understand its exact functions [1].