C57BL/6JCya-Acsbg1em1/Cya
Common Name:
Acsbg1-KO
Product ID:
S-KO-17664
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Acsbg1-KO
Strain ID
KOCMP-94180-Acsbg1-B6J-VB
Gene Name
Product ID
S-KO-17664
Gene Alias
BG1; Bgm; E230019G03Rik; GR-LACS; Lpd
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
9
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Acsbg1em1/Cya mice (Catalog S-KO-17664) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000034822
NCBI RefSeq
NM_053178.2
Target Region
Exon 2
Size of Effective Region
~1.1 kb
Detailed Document
Overview of Gene Research
Acsbg1, short for Acyl-CoA Synthetase Bubble Gum 1, is a gene involved in fatty acid metabolism. It is part of the ACSL family, facilitating the activation of long-chain fatty acids (LCFAs) and their integration into essential lipid species. This process supports vital functions like membrane formation, myelination, and energy production, and is crucial for maintaining lipid homeostasis in various biological systems [4,5].
Genetic deletion of Acsbg1 in mice causes mitochondrial dysfunction and dampens other metabolic pathways. In Treg cells, Acsbg1 is selectively expressed, and its deficiency impairs Treg cell homeostasis, leading to an inability to resolve lung inflammation [1]. In CD4+ T cells, Acsbg1 deficiency results in impaired TH17 and in vitro-induced Treg (iTreg) cell differentiation, exacerbating colitis in adoptive transfer models [3]. In a mouse model of obesity-accelerated breast cancer, breast cancer cells in obese animals upregulate Acsbg1 to promote creatine-dependent tumor progression [2]. In the context of X-linked adrenoleukodystrophy (XALD), an Acsbg1 knockout mouse model showed developmental and compositional changes in fatty acid levels in the brain, though it's unlikely that Acsbg1 directly contributes to XALD pathology [4,5]. In diabetic cardiomyopathy rat models, Acsbg1 expression is significantly increased in the model group compared to the control group, and it may be associated with fatty acid metabolism and affect the occurrence and progression of the disease through the lysosome [6].
In summary, Acsbg1 plays essential roles in lipid metabolism, immune cell homeostasis, and differentiation, as well as in disease-related processes such as obesity-driven breast cancer and diabetic cardiomyopathy. The use of Acsbg1 knockout mouse models has been instrumental in uncovering these functions, providing valuable insights into the underlying mechanisms of these biological processes and diseases.
References:
1. Kanno, Toshio, Nakajima, Takahiro, Kawashima, Yusuke, Nakayama, Toshinori, Endo, Yusuke. . Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue Treg cell homeostasis. In Cell reports, 37, 109921. doi:10.1016/j.celrep.2021.109921. https://pubmed.ncbi.nlm.nih.gov/34758300/
2. Maguire, Olivia A, Ackerman, Sarah E, Szwed, Sarah K, Kazak, Lawrence, Cohen, Paul. 2021. Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer. In Cell metabolism, 33, 499-512.e6. doi:10.1016/j.cmet.2021.01.018. https://pubmed.ncbi.nlm.nih.gov/33596409/
3. Palatella, Martina, Kruse, Friederike, Glage, Silke, Greweling-Pils, Marina, Huehn, Jochen. 2025. Acsbg1 regulates differentiation and inflammatory properties of CD4+ T cells. In European journal of microbiology & immunology, 15, 21-31. doi:10.1556/1886.2025.00003. https://pubmed.ncbi.nlm.nih.gov/39937199/
4. Ye, Xiaoli, Li, Yuanyuan, González-Lamuño, Domingo, Smith, Kirby D, Watkins, Paul A. 2024. Role of ACSBG1 in brain lipid metabolism and X-linked adrenoleukodystrophy pathogenesis: Insights from a knockout mouse model. In bioRxiv : the preprint server for biology, , . doi:10.1101/2024.06.19.599741. https://pubmed.ncbi.nlm.nih.gov/38948805/
5. Ye, Xiaoli, Li, Yuanyuan, González-Lamuño, Domingo, Smith, Kirby D, Watkins, Paul A. 2024. Role of ACSBG1 in Brain Lipid Metabolism and X-Linked Adrenoleukodystrophy Pathogenesis: Insights from a Knockout Mouse Model. In Cells, 13, . doi:10.3390/cells13201687. https://pubmed.ncbi.nlm.nih.gov/39451204/
6. Huang, Xun, Wang, Yunhong, Wan, Rong, You, Zhigang, Huang, Lin. 2025. Identification of lipid metabolism-related genes in dapagliflozin treated rats with diabetic cardiomyopathy by bioinformatics. In Frontiers in endocrinology, 16, 1525831. doi:10.3389/fendo.2025.1525831. https://pubmed.ncbi.nlm.nih.gov/40182633/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen