C57BL/6JCya-Sykem1/Cya
Common Name:
Syk-KO
Product ID:
S-KO-17981
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Syk-KO
Strain ID
KOCMP-20963-Syk-B6J-VA
Gene Name
Product ID
S-KO-17981
Gene Alias
Sykb
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
13
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Sykem1/Cya mice (Catalog S-KO-17981) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000120135
NCBI RefSeq
NM_001198977
Target Region
Exon 3
Size of Effective Region
~1.8 kb
Detailed Document
Overview of Gene Research
Syk, short for spleen tyrosine kinase, is a non-receptor tyrosine kinase. It is highly expressed in hematopoietic cells and plays crucial roles in diverse biological functions. It is a key player in adaptive immune receptor signalling, and also mediates processes like cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation, and vascular development. It is activated by C-type lectins and integrins, and activates pathways such as the CARD9-BCL-10-MALT1 pathway and the NLRP3 inflammasome [1].
Syk has been implicated in numerous diseases. In autoimmune diseases like immune thrombocytopenia (ITP), rheumatoid arthritis, and systemic lupus erythematosus, Syk-signaling pathway is a potential target for treatment. Fostamatinib, a Syk inhibitor, has shown clinical response in ITP patients, including those refractory to other treatments [2,7]. In hematological malignancies, Syk is recognized as a critical element in the B-cell receptor signaling pathway, and several oral Syk inhibitors are being assessed in clinical trials [3]. In solid tumors, it shows a paradoxical role, acting as a tumor suppressor in some cancers while driving tumor growth in others [4]. In cardio-cerebrovascular diseases such as atherosclerosis, heart failure, and diabetic cardiomyopathy, Syk is involved in their progression [5]. Also, in Helicobacter pylori-induced gastric mucosal inflammatory responses, Syk activation leads to up-regulation of proinflammatory genes [6].
In conclusion, Syk is essential for multiple biological functions from immune responses to cell-cell interactions. The study of Syk using various models, potentially including KO/CKO mouse models (although not explicitly detailed in the given references about these models), has significantly contributed to understanding its role in diseases like autoimmune disorders, hematological malignancies, solid tumors, cardio-cerebrovascular diseases, and gastric inflammatory responses. This knowledge provides a basis for developing therapeutic strategies targeting Syk.
References：
1. Mócsai, Attila, Ruland, Jürgen, Tybulewicz, Victor L J. . The SYK tyrosine kinase: a crucial player in diverse biological functions. In Nature reviews. Immunology, 10, 387-402. doi:10.1038/nri2765. https://pubmed.ncbi.nlm.nih.gov/20467426/
2. Cooper, Nichola, Ghanima, Waleed, Hill, Quentin A, Markovtsov, Vadim, Kessler, Craig. 2022. Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib. In Platelets, 34, 2131751. doi:10.1080/09537104.2022.2131751. https://pubmed.ncbi.nlm.nih.gov/36331249/
3. Liu, Delong, Mamorska-Dyga, Aleksandra. 2017. Syk inhibitors in clinical development for hematological malignancies. In Journal of hematology & oncology, 10, 145. doi:10.1186/s13045-017-0512-1. https://pubmed.ncbi.nlm.nih.gov/28754125/
4. Joshi, Shweta. 2024. New insights into SYK targeting in solid tumors. In Trends in pharmacological sciences, 45, 904-918. doi:10.1016/j.tips.2024.08.006. https://pubmed.ncbi.nlm.nih.gov/39322438/
5. Li, Mohan, Wang, Pengbo, Zou, Yuanming, Zhang, Naijin, Sun, Yingxian. 2023. Spleen tyrosine kinase (SYK) signals are implicated in cardio-cerebrovascular diseases. In Heliyon, 9, e15625. doi:10.1016/j.heliyon.2023.e15625. https://pubmed.ncbi.nlm.nih.gov/37180910/
6. Slomiany, Bronislaw L, Slomiany, Amalia. 2019. Syk: a new target for attenuation of Helicobacter pylori-induced gastric mucosal inflammatory responses. In Inflammopharmacology, 27, 203-211. doi:10.1007/s10787-019-00577-6. https://pubmed.ncbi.nlm.nih.gov/30820719/
7. Deng, Guo-Min, Kyttaris, Vasileios C, Tsokos, George C. 2016. Targeting Syk in Autoimmune Rheumatic Diseases. In Frontiers in immunology, 7, 78. doi:10.3389/fimmu.2016.00078. https://pubmed.ncbi.nlm.nih.gov/27014261/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen