C57BL/6JCya-Cblifem1/Cya
Common Name
Cblif-KO
Product ID
S-KO-18093
Backgroud
C57BL/6JCya
Strain ID
KOCMP-14603-Cblif-B6J-VB
When using this mouse strain in a publication, please cite “Cblif-KO Mouse (Catalog S-KO-18093) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Cblif-KO
Strain ID
KOCMP-14603-Cblif-B6J-VB
Gene Name
Product ID
S-KO-18093
Gene Alias
Gif, IF, INF
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 19
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000025585
NCBI RefSeq
NM_008118
Target Region
Exon 5
Size of Effective Region
~1.2 kb
Overview of Gene Research
Cblif, related to the transport of vitamin B12 (cobalamin, Cbl), is involved in the complex process of Cbl assimilation in the organism [2]. During Cbl absorption, Cbl binds to glycoproteins like Hc and intrinsic factor (IF), and Cblif might play a role in this pathway, which is crucial for normal physiological functions as vitamin B12 is essential for cell metabolism, DNA synthesis, and nerve function [2].
In a study assessing the association between polymorphisms within genes involved in vitamin B12 transport and nonsyndromic cleft lip with or without cleft palate (NSCL/P) in Chile, variant genotypes for Cblif were obtained from a single nucleotide polymorphisms array among 247 cases and 453 controls [1]. However, after multiple comparison corrections, only a polymorphism in CUBN remained associated with NSCL/P, and no direct significant associations of Cblif with NSCL/P were reported in this study [1].
In conclusion, Cblif is likely important in the vitamin B12 transport pathway, which is essential for multiple physiological processes. Although the Chilean study did not show a direct association of Cblif polymorphisms with NSCL/P, further research may clarify its role in this and other disease conditions related to vitamin B12 metabolism.
References：
1. Suazo, José, Salamanca, Carlos, Cáceres-Rojas, Gabriela, Leiva, Noemi, Pardo, Rosa. 2022. Vitamin B12 Transport Genes and Nonsyndromic Cleft Lip With or Without Cleft Palate in Chile. In Reproductive sciences (Thousand Oaks, Calif.), 29, 2921-2926. doi:10.1007/s43032-022-00957-4. https://pubmed.ncbi.nlm.nih.gov/35471549/
2. Nicolas, J P, Guéant, J L. . Gastric intrinsic factor and its receptor. In Bailliere's clinical haematology, 8, 515-31. doi:. https://pubmed.ncbi.nlm.nih.gov/8534960/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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