C57BL/6JCya-Pla1aem1/Cya
Common Name
Pla1a-KO
Product ID
S-KO-18147
Backgroud
C57BL/6JCya
Strain ID
KOCMP-85031-Pla1a-B6J-VB
When using this mouse strain in a publication, please cite “Pla1a-KO Mouse (Catalog S-KO-18147) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Pla1a-KO
Strain ID
KOCMP-85031-Pla1a-B6J-VB
Gene Name
Product ID
S-KO-18147
Gene Alias
Ps-pla1, Pspla1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 16
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000002926
NCBI RefSeq
NM_134102.4
Target Region
Exon 2
Size of Effective Region
~2.0 kb
Overview of Gene Research
PLA1A, also known as phosphatidylserine-specific phospholipase A1-alpha, belongs to the pancreatic lipase family. It specifically hydrolyzes the sn-1 fatty acid of phosphatidylserine (PS) or 1-acyl-lysophosphatidylserine (1-acyl-lysoPS), producing unsaturated lysoPS species. It is involved in multiple biological processes such as the antiviral innate immune response, cholesterol transportation, and the regulation of immune cell maturation and functions [2].
In a mouse model of mannan-induced psoriatic arthritis (MIP), Pla1a−/− mice showed a reduced susceptibility to MIP with less bone erosions and decreased levels of cytokines like IL-17, KC, IP-10, MIP-1β, LIF, and VEGF in hind paw tissues. CD4+ T cells in lymph nodes increased in Pla1a−/− mice, contributing to a higher ratio of CD3+ to CD19+ and CD4+ to CD8+ in the MIP model. This indicates that PLA1A may contribute to MIP through increased lymphocyte activation, potentially those producing IL-17 [1].
In conclusion, PLA1A is crucial in multiple biological processes. The study of Pla1a−/− mouse models has revealed its role in psoriatic arthritis, suggesting that it could be a potential target for treating such inflammatory diseases. Additionally, its functions in immune regulation, antiviral responses, and lipid-related processes make it an important gene for understanding various physiological and pathological conditions [1,2].
References：
1. Zhao, Yang, Aoudjit, Fawzi, Bourgoin, Sylvain G. 2022. Phospholipase A1 Member A Deficiency Alleviates Mannan-Induced Psoriatic Arthritis in Mice Model. In International journal of molecular sciences, 23, . doi:10.3390/ijms23158559. https://pubmed.ncbi.nlm.nih.gov/35955693/
2. Zhao, Yang, Hasse, Stephan, Bourgoin, Sylvain G. 2021. Phosphatidylserine-specific phospholipase A1: A friend or the devil in disguise. In Progress in lipid research, 83, 101112. doi:10.1016/j.plipres.2021.101112. https://pubmed.ncbi.nlm.nih.gov/34166709/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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