C57BL/6JCya-Actrt3em1/Cya
Common Name:
Actrt3-KO
Product ID:
S-KO-18185
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Actrt3-KO
Strain ID
KOCMP-76652-Actrt3-B6J-VB
Gene Name
Product ID
S-KO-18185
Gene Alias
1700119I24Rik; ARP-T3; Arpm1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Actrt3em1/Cya mice (Catalog S-KO-18185) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000047630
NCBI RefSeq
NM_029690.2
Target Region
Exon 2
Size of Effective Region
~2.7 kb
Detailed Document
Overview of Gene Research
Actrt3, an actin-related protein, has been implicated in important biological processes. It may be involved in telomere maintenance and has connections to the development of multiple cancers. It also seems to play a role in B-cell activation, suggesting its importance in immune-related pathways [1,2].
Multi-tissue transcriptome-wide association study (TWAS) detected an association between Actrt3 in the 3q26 region and genes involved in telomere maintenance, which is related to the development of multiple cancers [1,3]. In the study of B-cell activation, Actrt3 was determined as a crucial gene in the Be1 network, indicating its significance in the molecular mechanisms of B-cell activation [2].
In conclusion, Actrt3 is involved in telomere maintenance and B-cell activation processes. Its association with multiple cancers through telomere-related mechanisms and its role in B-cell activation networks contribute to our understanding of cancer development and immune-related functions. Studies on Actrt3 help to uncover shared mechanisms in carcinogenesis and immune-related diseases, providing potential insights for prevention and intervention strategies.
References：
1. Middha, Pooja, Kachuri, Linda, Nierenberg, Jovia L, Sakoda, Lori C, Witte, John S. 2024. Unraveling the genetic landscape of susceptibility to multiple primary cancers. In medRxiv : the preprint server for health sciences, , . doi:10.1101/2024.10.29.24316326. https://pubmed.ncbi.nlm.nih.gov/39574869/
2. Fatehi, Razieh. . Assessment of the genes and molecular mechanisms of B cells activation through systems biology approaches. In Human antibodies, 28, 83-87. doi:10.3233/HAB-190393. https://pubmed.ncbi.nlm.nih.gov/31524152/
3. Middha, Pooja, Kachuri, Linda, Nierenberg, Jovia L, Sakoda, Lori C, Witte, John S. 2025. Unraveling the genetic landscape of susceptibility to multiple primary cancers. In HGG advances, 6, 100413. doi:10.1016/j.xhgg.2025.100413. https://pubmed.ncbi.nlm.nih.gov/39910817/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen