C57BL/6JCya-Actrt3em1/Cya
Common Name
Actrt3-KO
Product ID
S-KO-18185
Backgroud
C57BL/6JCya
Strain ID
KOCMP-76652-Actrt3-B6J-VB
When using this mouse strain in a publication, please cite “Actrt3-KO Mouse (Catalog S-KO-18185) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Actrt3-KO
Strain ID
KOCMP-76652-Actrt3-B6J-VB
Gene Name
Product ID
S-KO-18185
Gene Alias
1700119I24Rik, ARP-T3, Arpm1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 3
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000047630
NCBI RefSeq
NM_029690.2
Target Region
Exon 2
Size of Effective Region
~2.7 kb
Overview of Gene Research
Actrt3, an actin-related protein, has been implicated in important biological processes. It may be involved in telomere maintenance and has connections to the development of multiple cancers. It also seems to play a role in B-cell activation, suggesting its importance in immune-related pathways [1,2].
Multi-tissue transcriptome-wide association study (TWAS) detected an association between Actrt3 in the 3q26 region and genes involved in telomere maintenance, which is related to the development of multiple cancers [1,3]. In the study of B-cell activation, Actrt3 was determined as a crucial gene in the Be1 network, indicating its significance in the molecular mechanisms of B-cell activation [2].
In conclusion, Actrt3 is involved in telomere maintenance and B-cell activation processes. Its association with multiple cancers through telomere-related mechanisms and its role in B-cell activation networks contribute to our understanding of cancer development and immune-related functions. Studies on Actrt3 help to uncover shared mechanisms in carcinogenesis and immune-related diseases, providing potential insights for prevention and intervention strategies.
References：
1. Middha, Pooja, Kachuri, Linda, Nierenberg, Jovia L, Sakoda, Lori C, Witte, John S. 2024. Unraveling the genetic landscape of susceptibility to multiple primary cancers. In medRxiv : the preprint server for health sciences, , . doi:10.1101/2024.10.29.24316326. https://pubmed.ncbi.nlm.nih.gov/39574869/
2. Fatehi, Razieh. . Assessment of the genes and molecular mechanisms of B cells activation through systems biology approaches. In Human antibodies, 28, 83-87. doi:10.3233/HAB-190393. https://pubmed.ncbi.nlm.nih.gov/31524152/
3. Middha, Pooja, Kachuri, Linda, Nierenberg, Jovia L, Sakoda, Lori C, Witte, John S. 2025. Unraveling the genetic landscape of susceptibility to multiple primary cancers. In HGG advances, 6, 100413. doi:10.1016/j.xhgg.2025.100413. https://pubmed.ncbi.nlm.nih.gov/39910817/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.