C57BL/6JCya-Il5raem1/Cya
Common Name:
Il5ra-KO
Product ID:
S-KO-18230
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Il5ra-KO
Strain ID
KOCMP-16192-Il5ra-B6J-VC
Gene Name
Product ID
S-KO-18230
Gene Alias
CD125; CDw125; Il5r
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
6
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Il5raem1/Cya mice (Catalog S-KO-18230) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000204659
NCBI RefSeq
NM_008370
Target Region
Exon 6
Size of Effective Region
~1.1 kb
Detailed Document
Overview of Gene Research
Il5ra, also known as Interleukin 5 receptor, alpha, is a well-established regulator of eosinophil activation. It is involved in eosinophil-mediated anti-parasitic activities and allergic reactions [2]. It has been implicated in pathways such as the PI3K-Akt signaling pathway and Natural killer cell mediated cytotoxicity [1].
In multiple myeloma, IL5RA was upregulated and associated with disease progression. In vitro and in vivo experiments showed its involvement in apoptosis, proliferation, and drug resistance of myeloma cells, suggesting it could be an immunogenic cell death-related predictor [1].
In pulmonary fibrosis, epithelial IL5RA was upregulated during disease progression and promoted epithelial-mesenchymal transition (EMT) via the Jak2/STAT3 cascade. Inhibiting IL5RA might offer a therapeutic strategy [2].
In chronic obstructive pulmonary disease (COPD), IL5RA gene variants were significantly associated with susceptibility to the disease. Rs13097407 reduced susceptibility, while rs3856850 increased the risk, and the effects were influenced by sex and smoking [3].
In conclusion, Il5ra plays essential roles in regulating eosinophil activation and is involved in multiple biological processes and diseases. Studies on Il5ra, especially through in vitro and in vivo models, have provided insights into its role in diseases like multiple myeloma, pulmonary fibrosis, and COPD, which may contribute to the development of new therapeutic strategies.
References:
1. Xu, Cong, Gao, Meng, Zhang, Junhua, Fu, Yunfeng. 2023. IL5RA as an immunogenic cell death-related predictor in progression and therapeutic response of multiple myeloma. In Scientific reports, 13, 8528. doi:10.1038/s41598-023-35378-z. https://pubmed.ncbi.nlm.nih.gov/37236993/
2. Chen, Shuyun, Zhao, Tiantian, Xie, Shiguang, Wan, Xuan. 2024. Epithelial IL5RA promotes epithelial-mesenchymal transition in pulmonary fibrosis via Jak2/STAT3 cascade. In Pulmonary pharmacology & therapeutics, 84, 102286. doi:10.1016/j.pupt.2024.102286. https://pubmed.ncbi.nlm.nih.gov/38191068/
3. Li, Siguang, Lin, Lingsang, Zhao, Jie, Ding, Yipeng, Xie, Tian. 2023. The Study of the Influence of IL5RA Variants on Chronic Obstructive Pulmonary Disease. In COPD, 20, 338-347. doi:10.1080/15412555.2023.2270729. https://pubmed.ncbi.nlm.nih.gov/37905709/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen