C57BL/6JCya-Smim26em1/Cya
Common Name
Smim26-KO
Product ID
S-KO-18232
Backgroud
C57BL/6JCya
Strain ID
KOCMP-228715-Smim26-B6J-VB
When using this mouse strain in a publication, please cite “Smim26-KO Mouse (Catalog S-KO-18232) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Smim26-KO
Strain ID
KOCMP-228715-Smim26-B6J-VB
Gene Name
Product ID
S-KO-18232
Gene Alias
Gm561
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 2
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000136628
NCBI RefSeq
NM_001033297.3
Target Region
Exon 2
Size of Effective Region
~1.9 kb
Overview of Gene Research
Smim26 is a microprotein encoded by the long non-coding RNA LINC00493. It is localized in mitochondria and plays an anti-metastatic role in clear cell renal cell carcinoma (ccRCC). It functions through interacting with acylglycerol kinase (AGK) and glutathione transport regulator SLC25A11 via its N-terminus, which affects mitochondrial localization of AGK and AKT phosphorylation, as well as mitochondrial glutathione import and respiratory efficiency [1].
Research shows that LINC00493 is recognized by RNA-binding protein PABPC4 and transferred to ribosomes for translation of SMIM26. Knockdown and overexpression experiments suggest that both LINC00493/SMIM26 transcript and protein affect cell viability, but in opposite ways [2].
In conclusion, Smim26 is a microprotein with an anti-metastatic function in ccRCC. Studies on its gene and protein function help understand the biological processes related to cancer metastasis and cell viability, providing insights into potential therapeutic strategies for ccRCC.
References：
1. Meng, Kun, Lu, Shaohua, Li, Yu-Ying, Zhang, Chris Zhiyi, He, Qing-Yu. 2023. LINC00493-encoded microprotein SMIM26 exerts anti-metastatic activity in renal cell carcinoma. In EMBO reports, 24, e56282. doi:10.15252/embr.202256282. https://pubmed.ncbi.nlm.nih.gov/37009826/
2. Konina, Daria, Sparber, Peter, Viakhireva, Iuliia, Filatova, Alexandra, Skoblov, Mikhail. 2021. Investigation of LINC00493/SMIM26 Gene Suggests Its Dual Functioning at mRNA and Protein Level. In International journal of molecular sciences, 22, . doi:10.3390/ijms22168477. https://pubmed.ncbi.nlm.nih.gov/34445188/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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