C57BL/6JCya-Saxo4em1/Cya
Common Name
Saxo4-KO
Product ID
S-KO-18316
Backgroud
C57BL/6JCya
Strain ID
KOCMP-67752-Saxo4-B6J-VB
When using this mouse strain in a publication, please cite “Saxo4-KO Mouse (Catalog S-KO-18316) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Saxo4-KO
Strain ID
KOCMP-67752-Saxo4-B6J-VB
Gene Name
Product ID
S-KO-18316
Gene Alias
4930579J09Rik, IIIG9, IIIG9L, IIIG9S, Ppp1r32
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 19
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000237522
NCBI RefSeq
NM_001368184.1
Target Region
Exon 3~11
Size of Effective Region
~5.4 kb
Overview of Gene Research
Saxo4 is one of the genes enriched in male reproductive tissues. However, little is known about its key aliases, associated pathways, and exact function prior to certain studies. Genetic models, like KO mouse models, can be valuable tools for exploring its function [1].
In a study using the CRISPR/Cas9 system to generate gene-deficient mice, including those lacking Saxo4, the gene-deficient mice exhibited normal fertility in natural breeding experiments. This indicates that Saxo4 is not essential for male fertility [1].
In conclusion, through model-based research, Saxo4 has been shown not to be essential for male fertility. The use of Saxo4 KO mouse models has contributed to understanding the dispensability of genes in male reproductive biology, preventing potential duplicate efforts in generating knockout mice for genes without an apparent male-fertility-related phenotype [1].
References：
1. Nguyen, Tuyen Thi Thanh, Tokuhiro, Keizo, Shimada, Keisuke, Kiyozumi, Daiji, Ikawa, Masahito. 2024. Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. In Frontiers in cell and developmental biology, 12, 1411162. doi:10.3389/fcell.2024.1411162. https://pubmed.ncbi.nlm.nih.gov/38835510/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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