C57BL/6JCya-Ccdc27em1/Cya
Common Name:
Ccdc27-KO
Product ID:
S-KO-18363
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Ccdc27-KO
Strain ID
KOCMP-381580-Ccdc27-B6J-VA
Gene Name
Product ID
S-KO-18363
Gene Alias
Gm1035
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
4
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ccdc27em1/Cya mice (Catalog S-KO-18363) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000047207
NCBI RefSeq
NM_001033455
Target Region
Exon 2
Size of Effective Region
~0.7 kb
Detailed Document
Overview of Gene Research
Ccdc27, whose full function remains to be fully elucidated, was identified as a candidate gene in a study focused on low bone mineral density (BMD) [1]. It is likely involved in pathways related to bone metabolism and development, given its association with BMD-a crucial determinant of osteoporosis risk. Genetic models, such as KO or CKO mouse models, could potentially provide more insights into its precise role in these processes.
In a genetic analysis of 39 osteoporosis pedigrees, Ccdc27 was among the candidate genes associated with BMD. Linkage and linkage disequilibrium analyses of SNPs in the 1p36 region on chromosome 1, where a quantitative trait locus (QTL) for BMD maps, identified Ccdc27 as having at least one SNP with p < 0.001 for at least one BMD trait, suggesting its potential influence on BMD [1].
In conclusion, Ccdc27 is a gene potentially involved in regulating BMD, with its discovery contributing to the understanding of genetic factors in osteoporosis. Although no KO/CKO mouse model findings were presented in the given reference, future studies using such models could further clarify its role in bone-related biological processes and osteoporosis-associated conditions. [1]
References：
1. Zhang, H, Sol-Church, K, Rydbeck, H, Spotila, L D, Devoto, M. 2008. High resolution linkage and linkage disequilibrium analyses of chromosome 1p36 SNPs identify new positional candidate genes for low bone mineral density. In Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 20, 341-6. doi:10.1007/s00198-008-0668-1. https://pubmed.ncbi.nlm.nih.gov/18597038/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen