C57BL/6JCya-Ccdc27em1/Cya
Common Name
Ccdc27-KO
Product ID
S-KO-18363
Backgroud
C57BL/6JCya
Strain ID
KOCMP-381580-Ccdc27-B6J-VA
Status
When using this mouse strain in a publication, please cite “Ccdc27-KO Mouse (Catalog S-KO-18363) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Ccdc27-KO
Strain ID
KOCMP-381580-Ccdc27-B6J-VA
Gene Name
Product ID
S-KO-18363
Gene Alias
Gm1035
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 4
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000047207
NCBI RefSeq
NM_001033455
Target Region
Exon 2
Size of Effective Region
~0.7 kb
Overview of Gene Research
Ccdc27, whose full function remains to be fully elucidated, was identified as a candidate gene in a study focused on low bone mineral density (BMD) [1]. It is likely involved in pathways related to bone metabolism and development, given its association with BMD-a crucial determinant of osteoporosis risk. Genetic models, such as KO or CKO mouse models, could potentially provide more insights into its precise role in these processes.
In a genetic analysis of 39 osteoporosis pedigrees, Ccdc27 was among the candidate genes associated with BMD. Linkage and linkage disequilibrium analyses of SNPs in the 1p36 region on chromosome 1, where a quantitative trait locus (QTL) for BMD maps, identified Ccdc27 as having at least one SNP with p < 0.001 for at least one BMD trait, suggesting its potential influence on BMD [1].
In conclusion, Ccdc27 is a gene potentially involved in regulating BMD, with its discovery contributing to the understanding of genetic factors in osteoporosis. Although no KO/CKO mouse model findings were presented in the given reference, future studies using such models could further clarify its role in bone-related biological processes and osteoporosis-associated conditions. [1]
References：
1. Zhang, H, Sol-Church, K, Rydbeck, H, Spotila, L D, Devoto, M. 2008. High resolution linkage and linkage disequilibrium analyses of chromosome 1p36 SNPs identify new positional candidate genes for low bone mineral density. In Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 20, 341-6. doi:10.1007/s00198-008-0668-1. https://pubmed.ncbi.nlm.nih.gov/18597038/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.