C57BL/6JCya-Spnem1/Cya
Common Name
Spn-KO
Product ID
S-KO-18524
Backgroud
C57BL/6JCya
Strain ID
KOCMP-20737-Spn-B6J-VB
When using this mouse strain in a publication, please cite “Spn-KO Mouse (Catalog S-KO-18524) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Spn-KO
Strain ID
KOCMP-20737-Spn-B6J-VB
Gene Name
Product ID
S-KO-18524
Gene Alias
A630014B01Rik, Cd43, Galgp, Ly-48, Ly48
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000049931
NCBI RefSeq
NM_009259
Target Region
Exon 1~2
Size of Effective Region
~5.1 kb
Overview of Gene Research
Spn, also known as SPINOPHILIN, PPP1R9B or NEURABIN-2, is a multifunctional protein. It regulates protein-protein interactions in different cell signaling pathways and is one of the regulatory subunits of protein phosphatase 1 (PP1), involved in the dephosphorylation of retinoblastoma protein (pRB) during the cell cycle. The SPN gene has been described as a tumor suppressor [2].
In Drosophila, the spn-A/rad51 mutant (where spn-A is related to Spn) shows enhanced genomic damage, cell death and low-temperature sensitivity in somatic tissues. This indicates a role for spn-A in maintaining somatic tissue during larval and pupal stages and in temperature-sensitive cellular processes [1].
In conclusion, Spn is crucial in regulating cell-cycle-related phosphorylation events and acts as a tumor suppressor. Drosophila spn-A/rad51 mutant models have revealed its role in somatic tissue maintenance and temperature-sensitive processes, contributing to our understanding of tissue development and potentially related disease mechanisms.
References：
1. Khan, Chaitali, Muliyil, Sonia, Ayyub, Champakali, Rao, B J. 2020. spn-A/rad51 mutant exhibits enhanced genomic damage, cell death and low temperature sensitivity in somatic tissues. In Chromosoma, 130, 3-14. doi:10.1007/s00412-020-00746-5. https://pubmed.ncbi.nlm.nih.gov/33222024/
2. Verdugo-Sivianes, Eva M, Carnero, Amancio. 2022. SPINOPHILIN: A multiplayer tumor suppressor. In Genes & diseases, 10, 187-198. doi:10.1016/j.gendis.2021.12.021. https://pubmed.ncbi.nlm.nih.gov/37013033/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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