C57BL/6JCya-Tnfaip8l2em1/Cya
Common Name
Tnfaip8l2-KO
Product ID
S-KO-18580
Backgroud
C57BL/6JCya
Strain ID
KOCMP-69769-Tnfaip8l2-B6J-VA
When using this mouse strain in a publication, please cite “Tnfaip8l2-KO Mouse (Catalog S-KO-18580) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Tnfaip8l2-KO
Strain ID
KOCMP-69769-Tnfaip8l2-B6J-VA
Gene Name
Product ID
S-KO-18580
Gene Alias
1810019A08Rik, TIPE2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 3
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000013851
NCBI RefSeq
NM_027206
Target Region
Exon 2
Size of Effective Region
~0.9 kb
Overview of Gene Research
Tnfaip8l2, also known as TIPE2, is a newly identified immune negative regulator belonging to the TNFAIP8 family. It plays a crucial role in maintaining immune homeostasis, with its functions associated with multiple pathways. For instance, it can interact with the RAC1-MTORC1 axis, which is involved in autophagy and mTORC1-related signaling [1,2].
In Tnfaip8l2-deficient (Tnfaip8l2-/-) mouse models, several significant phenotypes were observed. Tnfaip8l2 deficiency led to features of oxidative stress in cochlear hair cells and age-related hearing degeneration, similar to mTORC1-over-activated Tsc1-cKO mice. Rapamycin, an mTORC1 inhibitor, mitigated the hearing dysfunction caused by Tnfaip8l2-deficiency. Mechanistically, TNFAIP8L2 was found to regulate mTORC1 signaling by inhibiting the GTPase activity of RHEB and RAC1 [2]. Additionally, in an LPS-induced mouse endotoxemia model, Tnfaip8l2 deficiency exacerbated the inflammatory response and lung injury by controlling the MTOR activity [1].
In conclusion, Tnfaip8l2 is essential for maintaining immune homeostasis and normal physiological functions. Through gene knockout mouse models, its role in age-related hearing loss and endotoxemia-induced lung injury has been revealed. These findings suggest Tnfaip8l2 could be a potential therapeutic target for related diseases [1,2].
References：
1. Li, Wen, Li, Yulan, Guan, Yetong, Li, Yan, Zhang, Lining. 2020. TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis. In Autophagy, 17, 1410-1425. doi:10.1080/15548627.2020.1761748. https://pubmed.ncbi.nlm.nih.gov/32460619/
2. Li, Wen, Li, Yu, Wang, Min, Gao, Jiangang, Fu, Xiaolong. 2025. TNFAIP8L2 maintains hair cell function and regulates age-related hearing loss via mTORC1 signaling. In Molecular therapy : the journal of the American Society of Gene Therapy, , . doi:10.1016/j.ymthe.2025.03.046. https://pubmed.ncbi.nlm.nih.gov/40165373/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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