C57BL/6JCya-Rbm47em1/Cya
Common Name:
Rbm47-KO
Product ID:
S-KO-18867
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Rbm47-KO
Strain ID
KOCMP-245945-Rbm47-B6J-VA
Gene Name
Product ID
S-KO-18867
Gene Alias
9530077J19Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
5
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Rbm47em1/Cya mice (Catalog S-KO-18867) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000167950
NCBI RefSeq
NM_001127382
Target Region
Exon 5
Size of Effective Region
~2.1 kb
Detailed Document
Overview of Gene Research
Rbm47, an RNA-binding protein, is crucial for embryonic endoderm development [1]. It contains three RNA recognition motif (RRM) domains and is conserved in vertebrates. Rbm47 is involved in post-transcriptional regulation of gene expression, immune homeostasis, and various signaling pathways such as Wnt/β-catenin [3].
Intestine-specific Rbm47-knockout (Rbm47-IKO) mice studies show that Rbm47 regulates intestinal injury, proliferation, and tumorigenesis. Rbm47-IKO mice exhibit increased proliferation, abnormal villus morphology, and adapt better to radiation injury and chemical-induced colitis. They are also protected against colitis-associated cancer, but aged Rbm47-IKO mice develop spontaneous polyposis [1]. In lung, K329R knockin (KI) mice with defective RBM47-ISGylation display heightened susceptibility to LPS-induced acute lung injury and lung tumorigenesis, indicating Rbm47-ISGylation's role in maintaining lung homeostasis [2].
In conclusion, Rbm47 plays essential roles in embryonic development, immune homeostasis, and tissue-specific functions like in the intestine and lung. Gene-knockout mouse models, such as Rbm47-IKO and K329R KI mice, have been instrumental in revealing its role in intestinal injury, tumorigenesis, and lung-related diseases, providing insights into its potential as a therapeutic target in these disease areas.
References:
1. Soleymanjahi, Saeed, Blanc, Valerie, Molitor, Elizabeth A, Rubin, Deborah C, Davidson, Nicholas O. 2023. RBM47 regulates intestinal injury and tumorigenesis by modifying proliferation, oxidative response, and inflammatory pathways. In JCI insight, 8, . doi:10.1172/jci.insight.161118. https://pubmed.ncbi.nlm.nih.gov/37014710/
2. Ding, Shihui, Pang, Xiquan, Luo, Shaoxiang, Dong, Zhiqiang, Zhang, Min. 2023. Dynamic RBM47 ISGylation confers broad immunoprotection against lung injury and tumorigenesis via TSC22D3 downregulation. In Cell death discovery, 9, 430. doi:10.1038/s41420-023-01736-z. https://pubmed.ncbi.nlm.nih.gov/38036512/
3. Shivalingappa, Pavan Kumar Mysuru, Sharma, Vaishali, Shiras, Anjali, Bapat, Sharmila A. 2021. RNA binding motif 47 (RBM47): emerging roles in vertebrate development, RNA editing and cancer. In Molecular and cellular biochemistry, 476, 4493-4505. doi:10.1007/s11010-021-04256-5. https://pubmed.ncbi.nlm.nih.gov/34499322/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen