Abcc2, also known as MRP2, is a member of the ABC transporter family. It is expressed at major physiological barriers like the canalicular membrane of liver cells, kidney proximal tubule epithelial cells, enterocytes, and syncytiotrophoblast of the placenta, localizing in the apical membranes. It functions as a multispecific transporter with dominant excretory functions, transporting various amphiphilic anions, especially phase II conjugates [1].

In gastric cancer, high Abcc2 expression correlates with better prognosis, and it can induce metabolic vulnerability and cellular ferroptosis via enhanced glutathione efflux. The 24C > T polymorphism is a key factor influencing its expression [2]. In non-small cell lung cancer, PFKP upregulates Abcc2 through the activation of NF-κB, promoting chemoresistance [3]. In Plutella xylostella, up-regulated Abcc2 expression is related to insecticide resistance [4]. In papillary renal cell carcinoma, ABCC2 brush-border expression correlates with higher gene expression and predicts survival outcomes [5]. In Spodoptera litura, ABCC2 is a functional receptor of Bacillus thuringiensis Cry1Ca [6].

In conclusion, Abcc2 is crucial in multiple biological and disease-related processes. Its functions range from metabolite and drug transport to influencing disease prognosis and drug resistance in various cancers and insecticide resistance in pests. The study of Abcc2 using different models helps understand its role in these processes, providing potential insights for disease treatment and pest control.