C57BL/6JCya-Abcc2em1/Cya
Common Name
Abcc2-KO
Product ID
S-KO-18868
Backgroud
C57BL/6JCya
Strain ID
KOCMP-12780-Abcc2-B6J-VB
Status
When using this mouse strain in a publication, please cite “Abcc2-KO Mouse (Catalog S-KO-18868) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Abcc2-KO
Strain ID
KOCMP-12780-Abcc2-B6J-VB
Gene Name
Product ID
S-KO-18868
Gene Alias
Mrp2, cMRP, Abc30, Cmoat
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 19
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000026208
NCBI RefSeq
NM_013806
Target Region
Exon 4~6
Size of Effective Region
~2.2 kb
Overview of Gene Research
Abcc2, also known as MRP2, is a member of the ABC transporter family. It is expressed at major physiological barriers like the canalicular membrane of liver cells, kidney proximal tubule epithelial cells, enterocytes, and syncytiotrophoblast of the placenta, localizing in the apical membranes. It functions as a multispecific transporter with dominant excretory functions, transporting various amphiphilic anions, especially phase II conjugates [1].
In gastric cancer, high Abcc2 expression correlates with better prognosis, and it can induce metabolic vulnerability and cellular ferroptosis via enhanced glutathione efflux. The 24C > T polymorphism is a key factor influencing its expression [2]. In non-small cell lung cancer, PFKP upregulates Abcc2 through the activation of NF-κB, promoting chemoresistance [3]. In Plutella xylostella, up-regulated Abcc2 expression is related to insecticide resistance [4]. In papillary renal cell carcinoma, ABCC2 brush-border expression correlates with higher gene expression and predicts survival outcomes [5]. In Spodoptera litura, ABCC2 is a functional receptor of Bacillus thuringiensis Cry1Ca [6].
In conclusion, Abcc2 is crucial in multiple biological and disease-related processes. Its functions range from metabolite and drug transport to influencing disease prognosis and drug resistance in various cancers and insecticide resistance in pests. The study of Abcc2 using different models helps understand its role in these processes, providing potential insights for disease treatment and pest control.
References：
1. Jemnitz, Katalin, Heredi-Szabo, Krisztina, Janossy, Judit, Vereczkey, Laszlo, Krajcsi, Peter. . ABCC2/Abcc2: a multispecific transporter with dominant excretory functions. In Drug metabolism reviews, 42, 402-36. doi:10.3109/03602530903491741. https://pubmed.ncbi.nlm.nih.gov/20082599/
2. Wang, Yiding, Gan, Xuejun, Cheng, Xiaojing, Ji, Jiafu, Li, Ziyu. . ABCC2 induces metabolic vulnerability and cellular ferroptosis via enhanced glutathione efflux in gastric cancer. In Clinical and translational medicine, 14, e1754. doi:10.1002/ctm2.1754. https://pubmed.ncbi.nlm.nih.gov/39095325/
3. Wang, Zimin, Wu, Sikai, Chen, Xin, Zhu, Jinrong, Shen, Jianfei. 2023. PFKP confers chemoresistance by upregulating ABCC2 transporter in non-small cell lung cancer. In Translational lung cancer research, 12, 2294-2309. doi:10.21037/tlcr-23-567. https://pubmed.ncbi.nlm.nih.gov/38090515/
4. Xu, Jie, Wang, Zanyong, Wang, Yafei, Deng, Xile, Zhou, Xiaomao. 2019. ABCC2 participates in the resistance of Plutella xylostella to chemical insecticides. In Pesticide biochemistry and physiology, 162, 52-59. doi:10.1016/j.pestbp.2019.08.010. https://pubmed.ncbi.nlm.nih.gov/31836054/
5. Castillo, Vincent Francis, Masoomian, Mehdi, Trpkov, Kiril, Hamdani, Malek, Saleeb, Rola M. 2023. ABCC2 brush-border expression predicts outcome in papillary renal cell carcinoma: a multi-institutional study of 254 cases. In Histopathology, 83, 949-958. doi:10.1111/his.15042. https://pubmed.ncbi.nlm.nih.gov/37680023/
6. Yao, Xue, Liu, Chen, Duan, Yunpeng, Wei, Jizhen, Liang, Gemei. 2021. ABCC2 is a functional receptor of Bacillus thuringiensis Cry1Ca in Spodoptera litura. In International journal of biological macromolecules, 194, 9-16. doi:10.1016/j.ijbiomac.2021.11.174. https://pubmed.ncbi.nlm.nih.gov/34861271/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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