C57BL/6JCya-Tpgs1em1/Cya
Common Name:
Tpgs1-KO
Product ID:
S-KO-18896
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Tpgs1-KO
Strain ID
KOCMP-110012-Tpgs1-B6J-VB
Gene Name
Product ID
S-KO-18896
Gene Alias
Gm16517; Gtrgeo22; PGs1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
10
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tpgs1em1/Cya mice (Catalog S-KO-18896) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000020552
NCBI RefSeq
NM_148934
Target Region
Exon 1
Size of Effective Region
~1.4 kb
Detailed Document
Overview of Gene Research
Tpgs1, also known as Tubulin polyglutamylase complex1, helps in microtubule polymerization. It is involved in multiple biological processes such as glucose transport, cellular movement, organization of intracellular structure, and intracellular transport [2]. It may also be associated with pathways related to the immune synapse formation, TCR signaling, and Wnt signaling [1,3].
In a study on narcolepsy type I, Tpgs1 was identified as one of the NT1-specific differentially expressed genes in CD4 T-cell subsets, which may play a role in the immune synapse formation and TCR signaling [1]. In a case study of an elderly individual with polymicrogyria, rare pathological/deleterious variants of Tpgs1 were found among genes involved in the regulation of Wnt signaling, potentially highlighting its contribution to this condition [3].
In conclusion, Tpgs1 has diverse functions in microtubule-related processes and seems to be associated with diseases like narcolepsy type I and polymicrogyria. These findings from relevant studies help in understanding the role of Tpgs1 in specific biological processes and disease conditions, providing insights into the underlying molecular mechanisms.
References：
1. Khajavi, Leila, Nguyen, Xuan-Hung, Queriault, Clémence, Zytnicki, Matthias, Liblau, Roland. 2023. The transcriptomics profiling of blood CD4 and CD8 T-cells in narcolepsy type I. In Frontiers in immunology, 14, 1249405. doi:10.3389/fimmu.2023.1249405. https://pubmed.ncbi.nlm.nih.gov/38077397/
2. Taneja, Nancy. . Mass Spectrometric Analysis of Proteins of L6 Skeletal Muscle Cells Under Different Glucose Conditions and Vitamin D Supplementation. In Protein and peptide letters, 25, 356-361. doi:10.2174/0929866525666180406142128. https://pubmed.ncbi.nlm.nih.gov/29623822/
3. Frolov, Andrey, Atwood, Stuart G, Guzman, Miguel A, Martin, John R. 2024. A Rare Case of Polymicrogyria in an Elderly Individual With Unique Polygenic Underlining. In Cureus, 16, e74300. doi:10.7759/cureus.74300. https://pubmed.ncbi.nlm.nih.gov/39717325/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen