Psmb6, encoding the 20S subunit beta 6 of the proteasome family, performs caspase-like proteasome activity. It is involved in multiple biological pathways, such as antigen presentation by MHC class I molecular [6]. It also plays a role in processes like fatty acid metabolism and is associated with the ubiquitin-proteasome pathway [5,7]. Genetic models, like gene knockout in zebrafish, help study its functions.

In multiple myeloma, knocking down Psmb6 increases sensitivity to bortezomib, suggesting it's a novel target for bortezomib-resistance [1]. In lung adenocarcinoma, high Psmb6 expression correlates with poor prognosis, and its knockdown inhibits cell proliferation, migration, and invasion while promoting apoptosis [2]. In zebrafish, psmb6 knockout leads to early embryonic death due to proteasome inactivity and neuronal apoptosis [3]. In multiple myeloma cell lines, Psmb6 knockout is lethal, and it's essential for cell survival, with its depletion restoring bortezomib sensitivity [4]. In mosquitoes, Psmb6 is associated with deltamethrin resistance, and its knockdown decreases cellular viability under deltamethrin treatment [7].

In conclusion, Psmb6 is crucial for proteasome function and cell survival. Studies using gene knockout models in different organisms have revealed its significance in various disease conditions, including multiple myeloma, lung adenocarcinoma, and deltamethrin-resistance in mosquitoes, providing potential therapeutic targets.